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    Ldlrad4 low density lipoprotein receptor class A domain containing 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679578, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ldlrad4provided by RGD
    Official Full Name
    low density lipoprotein receptor class A domain containing 4provided by RGD
    Primary source
    RGD:1587105
    See related
    Ensembl:ENSRNOG00000016879 AllianceGenome:RGD:1587105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable R-SMAD binding activity. Predicted to be involved in negative regulation of cell migration; negative regulation of epithelial to mesenchymal transition; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in Golgi membrane and early endosome membrane. Orthologous to human LDLRAD4 (low density lipoprotein receptor class A domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 56.2), Kidney (RPKM 51.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ldlrad4 in Genome Data Viewer
    Location:
    18q12.1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (63789089..64118166)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (61519253..61848403)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (63717423..64045224)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552297 Neighboring gene SEH1-like nucleoporin Neighboring gene centrosomal protein 192 Neighboring gene small nucleolar RNA SNORA33 Neighboring gene tubulin, alpha 1B, pseudogene 3 Neighboring gene uncharacterized LOC134482959 Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 118 Neighboring gene tRNA methyltransferase activator subunit 11-2, pseudogene 1 Neighboring gene family with sequence similarity 210, member A Neighboring gene RNA (guanine-7-) methyltransferase Neighboring gene melanocortin 5 receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C18 ORF1, a novel negative regulator of transforming growth factor-β signaling. Nakano N, et al. J Biol Chem, 2014 May 2. PMID 24627487, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables R-SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables R-SMAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of SMAD protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    low-density lipoprotein receptor class A domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271365.1 → NP_001258294.1  low-density lipoprotein receptor class A domain-containing protein 4

      See identical proteins and their annotated locations for NP_001258294.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      63789089..64118166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097102.2 → XP_038953030.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    2. XM_039097106.2 → XP_038953034.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    3. XM_039097104.2 → XP_038953032.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    4. XM_039097100.2 → XP_038953028.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    5. XM_063277574.1 → XP_063133644.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    6. XM_039097109.2 → XP_038953037.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    7. XM_063277575.1 → XP_063133645.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X4

    8. XM_039097101.2 → XP_038953029.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    9. XM_063277573.1 → XP_063133643.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6

    10. XM_039097105.2 → XP_038953033.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    11. XM_039097103.2 → XP_038953031.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Related
      ENSRNOP00000082880.1
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    12. XM_039097098.2 → XP_038953026.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    13. XM_039097112.2 → XP_038953040.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X2

      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    14. XM_039097107.2 → XP_038953035.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    15. XM_039097111.2 → XP_038953039.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    16. XM_039097110.2 → XP_038953038.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    17. XM_039097108.2 → XP_038953036.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZUC8, A6IXW6
      Conserved Domains (1) summary
      cd00112
      Location:16 → 47
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

    18. XM_039097117.2 → XP_038953045.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X6

      UniProtKB/TrEMBL
      A6IXW9

    19. XM_039097116.2 → XP_038953044.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X5

    20. XM_039097113.2 → XP_038953041.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K955, A6IXW8, F1LZA8
      Related
      ENSRNOP00000022717.6

    21. XM_063277576.1 → XP_063133646.1  low-density lipoprotein receptor class A domain-containing protein 4 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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