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    Rnf14 ring finger protein 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619577, updated on 6-Jun-2024

    Summary

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    Symbol
    Rnf14provided by RGD
    Full Name
    ring finger protein 14provided by RGD
    Primary source
    RGD:1589576
    See related
    Ensembl:ENSRNOG00000045637 AllianceGenome:RGD:1589576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ARA54
    Summary
    Predicted to enable androgen receptor binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Predicted to be involved in cellular protein metabolic process; positive regulation of nitrogen compound metabolic process; and regulation of androgen receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 728.6), Heart (RPKM 285.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rnf14 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (30381072..30406859)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (30131627..30155686)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (31443424..31468641)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene DAP3 binding cell death enhancer 1 Neighboring gene protocadherin 12 Neighboring gene U6 spliceosomal RNA Neighboring gene glucosamine-6-phosphate deaminase 1 Neighboring gene uncharacterized LOC134482933

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Regulation of androgen receptor transcriptional activity and specificity by RNF6-induced ubiquitination. Xu K, et al. Cancer Cell, 2009 Apr 7. PMID 19345326, Free PMC Article
    2. N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8. Ito K, et al. Eur J Biochem, 2001 May. PMID 11322894
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear androgen receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K6-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-RNA covalent cross-linking repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF14
    Names
    androgen receptor associated protein 54
    triad2 protein
    NP_001030167.1
    XP_006254699.1
    XP_006254701.1
    XP_017456519.1
    XP_038953004.1
    XP_038953007.1
    XP_063133607.1
    XP_063133608.1
    XP_063133609.1
    XP_063133610.1
    XP_063133611.1
    XP_063133612.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034995.1 → NP_001030167.1  E3 ubiquitin-protein ligase RNF14

      See identical proteins and their annotated locations for NP_001030167.1

      Status: PROVISIONAL

      Source sequence(s)
      BC103648
      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6
      Related
      ENSRNOP00000064970.1, ENSRNOT00000075159.2
      Conserved Domains (4) summary
      smart00647
      Location:294 → 355
      IBR; In Between Ring fingers
      cd16628
      Location:223 → 276
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:382 → 438
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7 → 133
      RWD; RWD domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      30381072..30406859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277540.1 → XP_063133610.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6

    2. XM_017601030.3 → XP_017456519.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6
      Related
      ENSRNOP00000082094.1
      Conserved Domains (4) summary
      smart00647
      Location:294 → 355
      IBR; In Between Ring fingers
      cd16628
      Location:223 → 276
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:382 → 438
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7 → 133
      RWD; RWD domain

    3. XM_006254637.4 → XP_006254699.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      See identical proteins and their annotated locations for XP_006254699.1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6
      Conserved Domains (4) summary
      smart00647
      Location:294 → 355
      IBR; In Between Ring fingers
      cd16628
      Location:223 → 276
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:382 → 438
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7 → 133
      RWD; RWD domain

    4. XM_063277541.1 → XP_063133611.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6

    5. XM_039097076.2 → XP_038953004.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6
      Conserved Domains (4) summary
      smart00647
      Location:294 → 355
      IBR; In Between Ring fingers
      cd16628
      Location:223 → 276
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:382 → 438
      IBR; IBR domain, a half RING-finger domain
      pfam05773
      Location:7 → 133
      RWD; RWD domain

    6. XM_063277537.1 → XP_063133607.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6

    7. XM_063277538.1 → XP_063133608.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6

    8. XM_063277539.1 → XP_063133609.1  E3 ubiquitin-protein ligase RNF14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTV5, A6J3F9, A6J3G1, Q3ZAU6

    9. XM_039097079.2 → XP_038953007.1  E3 ubiquitin-protein ligase RNF14 isoform X3

      Conserved Domains (2) summary
      cd16628
      Location:223 → 276
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam05773
      Location:7 → 133
      RWD; RWD domain

    10. XM_063277542.1 → XP_063133612.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A7D2, A6J3G3, B2GV23

    11. XM_006254639.5 → XP_006254701.1  E3 ubiquitin-protein ligase RNF14 isoform X2

      See identical proteins and their annotated locations for XP_006254701.1

      UniProtKB/TrEMBL
      A0A8I6A7D2, A6J3G3, B2GV23
      Conserved Domains (3) summary
      smart00647
      Location:168 → 229
      IBR; In Between Ring fingers
      cd16628
      Location:97 → 150
      RING-HC_RBR_RNF14; RING finger, HC subclass, found in RING finger protein 14 (RNF14) and similar proteins
      pfam01485
      Location:256 → 312
      IBR; IBR domain, a half RING-finger domain
    Nucleotide Protein Strain
    Heading Accession and Version

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