Fig4 FIG4 phosphoinositide 5-phosphatase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fig4provided by RGD
Official Full Name: FIG4 phosphoinositide 5-phosphataseprovided by RGD
Primary source: RGD:1311375
See related: Ensembl:ENSRNOG00000000312 AllianceGenome:RGD:1311375
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sac3; Kiaa0274; RGD1311375
Summary: Enables phosphatidylinositol bisphosphate phosphatase activity; phosphatidylinositol-3-phosphatase activity; and phosphatidylinositol-4-phosphate phosphatase activity. Involved in positive regulation of neuron projection development. Colocalizes with Golgi apparatus; endoplasmic reticulum; and recycling endosome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4J; Yunis-Varon syndrome; amyotrophic lateral sclerosis type 11; and bilateral parasagittal parieto-occipital polymicrogyria. Orthologous to human FIG4 (FIG4 phosphoinositide 5-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 63.9), Brain (RPKM 62.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (46183225..46306686, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (44600603..44724047, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (45922806..46044754, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol bisphosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-4-phosphate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myelin assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron development	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pigmentation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vacuole organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polyphosphoinositide phosphatase

Names: Sac domain-containing inositol phosphatase 3

NP_001040561.1

EC 3.1.3.16

EC 3.1.3.36

EC 3.1.3.86

XP_006256602.1

EC 3.1.3.16

EC 3.1.3.36

EC 3.1.3.86

XP_006256603.1

EC 3.1.3.16

EC 3.1.3.36

EC 3.1.3.86

XP_038954694.1

EC 3.1.3.16

EC 3.1.3.36

EC 3.1.3.86

XP_038954695.1

EC 3.1.3.16

EC 3.1.3.36

EC 3.1.3.86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047096.1 → NP_001040561.1 polyphosphoinositide phosphatase

See identical proteins and their annotated locations for NP_001040561.1

Status: PROVISIONAL

Source sequence(s)

DQ666853

UniProtKB/TrEMBL

A0A8I6ADY9, A6KTC8, F7ESC7, Q0Z843

Related

ENSRNOP00000000343.2, ENSRNOT00000000343.5

Conserved Domains (2) summary

COG5329
Location:14 → 636

COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]

pfam02383
Location:93 → 423

Syja_N; SacI homology domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

46183225..46306686 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256541.5 → XP_006256603.1 polyphosphoinositide phosphatase isoform X1

See identical proteins and their annotated locations for XP_006256603.1

UniProtKB/TrEMBL

A0A8I6ADY9, A6KTC9

Conserved Domains (1) summary

pfam02383
Location:6 → 308

Syja_N; SacI homology domain
XM_006256540.4 → XP_006256602.1 polyphosphoinositide phosphatase isoform X1

See identical proteins and their annotated locations for XP_006256602.1

UniProtKB/TrEMBL

A0A8I6ADY9, A6KTC9

Conserved Domains (1) summary

pfam02383
Location:6 → 308

Syja_N; SacI homology domain
XM_039098766.2 → XP_038954694.1 polyphosphoinositide phosphatase isoform X1

UniProtKB/TrEMBL

A0A8I6ADY9, A6KTC9

Conserved Domains (1) summary

pfam02383
Location:6 → 308

Syja_N; SacI homology domain
XM_039098767.2 → XP_038954695.1 polyphosphoinositide phosphatase isoform X2

Conserved Domains (1) summary

pfam02383
Location:93 → 423

Syja_N; SacI homology domain