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    Eif3l eukaryotic translation initiation factor 3, subunit L [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300069, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Eif3lprovided by RGD
    Official Full Name
    eukaryotic translation initiation factor 3, subunit Lprovided by RGD
    Primary source
    RGD:1308230
    See related
    AllianceGenome:RGD:1308230
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Eif3s6ip
    Summary
    Predicted to contribute to translation initiation factor activity. Predicted to be involved in translational initiation and viral translational termination-reinitiation. Predicted to be located in fibrillar center and nucleoplasm. Predicted to be part of eukaryotic translation initiation factor 3 complex. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 488.1), Kidney (RPKM 431.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Eif3l in Genome Data Viewer
    Location:
    7q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112522222..112544063)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110652565..110663614)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120320547..120331596)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene galanin receptor 3 Neighboring gene ankyrin repeat domain 54 Neighboring gene transfer RNA valine (anticodon AAC) 17 Neighboring gene MICAL-like 1 Neighboring gene similar to human chromosome 22 open reading frame 23 Neighboring gene RNA polymerase II, I and III subunit F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Further characterisation of the translational termination-reinitiation signal of the influenza B virus segment 7 RNA. Powell ML, et al. PLoS One, 2011 Feb 8. PMID 21347434, Free PMC Article
    2. PAF67, a novel protein that is associated with the initiation-competent form of RNA polymerase I. Seither P, et al. Biol Chem, 2001 Aug. PMID 11592397
    3. The scanning mechanism of eukaryotic translation initiation. Hinnebusch AG. Annu Rev Biochem, 2014. PMID 24499181
    4. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Lee AS, et al. Nature, 2015 Jun 4. PMID 25849773, Free PMC Article
    5. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Damoc E, et al. Mol Cell Proteomics, 2007 Jul. PMID 17322308

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC116337

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to translation initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in viral translational termination-reinitiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fibrillar center ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit L
    Names
    eukaryotic translation initiation factor 3, subunit 6 interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034134.2 → NP_001029306.2  eukaryotic translation initiation factor 3 subunit L

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I5ZLD0, A6HSP6, G3V7G9, Q498D2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112522222..112544063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263318.1 → XP_063119388.1  eukaryotic translation initiation factor 3 subunit L isoform X1

    2. XM_063263319.1 → XP_063119389.1  eukaryotic translation initiation factor 3 subunit L isoform X2

      UniProtKB/TrEMBL
      A0A8J8YB26
    Nucleotide Protein Strain
    Heading Accession and Version

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