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    Cd244l1 CD244 molecule like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64025, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cd244l1provided by RGD
    Official Full Name
    CD244 molecule like 1provided by RGD
    Primary source
    RGD:68400
    See related
    Ensembl:ENSRNOG00000068754 AllianceGenome:RGD:68400
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    2B4; Nmrk; Cd244
    Summary
    Predicted to enable MHC class I protein binding activity. Predicted to be involved in several processes, including positive regulation of gene expression; positive regulation of inositol phosphate biosynthetic process; and positive regulation of lymphocyte proliferation. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in rheumatoid arthritis. Orthologous to human CD244 (CD244 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 89.0), Lung (RPKM 23.6) and 5 other tissues See more
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    Genomic context

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    See Cd244l1 in Genome Data Viewer
    Location:
    13q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86547250..86569026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (84018887..84036612)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89959091..89995993)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene macrophage migration inhibitory factor, pseudogene 9 Neighboring gene natural killer cell receptor 2B4-like Neighboring gene 60S ribosomal protein L31 pseudogene Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene CD244 molecule Neighboring gene lymphocyte antigen 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition. Ames JB, et al. Biochemistry, 2005 May 3. PMID 15850375, Free PMC Article
    2. CD244 is expressed on dendritic cells and regulates their functions. Georgoudaki AM, et al. Immunol Cell Biol, 2015 Jul. PMID 25643613
    3. Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions. Kambayashi T, et al. J Immunol, 2001 Dec 15. PMID 11739483
    4. The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells. Speiser DE, et al. J Immunol, 2001 Dec 1. PMID 11714776
    5. Molecular characterization of the rat NK cell receptor 2B4. Kumaresan PR, et al. Mol Immunol, 2000 Aug-Sep. PMID 11275258

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. 2B4 adopts an immunoglobulin variable (V) domain fold, like that of domain 1 of CD2 and CD4 antigens, but with several unique structural and dynamic features related to ligand recognition and receptor function.
      Title: NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.
    2. CD48 is a CD2 and CD244 (2B4)-binding protein
      Title: Crystal structure and binding properties of the CD2 and CD244 (2B4)-binding protein, CD48.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class I protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in natural killer cell activation involved in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    natural killer cell receptor 2B4
    Names
    CD244 natural killer cell receptor 2B4
    Cd244 molecule, natural killer cell receptor 2B4
    NK cell type I receptor protein 2B4
    NKR2B4
    non-MHC restricted killing associated
    transmembrane NK cell receptor 2B4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022259.2 → NP_071595.2  natural killer cell receptor 2B4 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      F1LME3
      Related
      ENSRNOP00000000053.7, ENSRNOT00000000053.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      86547250..86569026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272572.1 → XP_063128642.1  natural killer cell receptor 2B4 isoform X1

    2. XM_063272573.1 → XP_063128643.1  natural killer cell receptor 2B4 isoform X1

    3. XM_063272574.1 → XP_063128644.1  natural killer cell receptor 2B4 isoform X2

    4. XM_039091060.2 → XP_038946988.1  natural killer cell receptor 2B4 isoform X2

      Conserved Domains (2) summary
      pfam11465
      Location:22 → 128
      Receptor_2B4; Natural killer cell receptor 2B4
      cd00096
      Location:25 → 27
      Ig; Ig strand A [structural motif]

    5. XM_039091061.2 → XP_038946989.1  natural killer cell receptor 2B4 isoform X4

      Conserved Domains (2) summary
      pfam11465
      Location:22 → 128
      Receptor_2B4; Natural killer cell receptor 2B4
      cd00096
      Location:25 → 27
      Ig; Ig strand A [structural motif]

    6. XM_063272575.1 → XP_063128645.1  natural killer cell receptor 2B4 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JLM2.1 GenPept UniProtKB/Swiss-Prot:Q9JLM2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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