Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp2c6provided by RGD
Official Full Name: cytochrome P450, family 2, subfamily C, polypeptide 6provided by RGD
Primary source: RGD:619934
See related: Ensembl:ENSRNOG00000024016 AllianceGenome:RGD:619934
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PB1; PTF2; CYPIIC6; Cyp2c6v1
Summary: Predicted to enable enzyme binding activity; heme binding activity; and monooxygenase activity. Involved in response to xenobiotic stimulus. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; invasive aspergillosis; multiple chemical sensitivity; and sickle cell anemia. Orthologous to human CYP2C19 (cytochrome P450 family 2 subfamily C member 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 6180.9) See more
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Genomic context

Location:: 1q53

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (247879058..247916804)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (237938521..237976238)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (147713879..147814410)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The protein levels of CYP 2c6, 2e1 and 2j3 increased in the ischemic region of the rat hearts, while the mRNA levels of CYPs were unchanged.
Title: Accumulation of cytochrome P450 induced by proteasome inhibition during cardiac ischemia.

Submit: New GeneRIF Correction

General gene information

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Markers

D1Got233 (e-PCR)
- UniSTS:112143

D1Wox24 (e-PCR)
- UniSTS:118114

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables arachidonic acid 14,15-epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IBA Inferred from Biological aspect of Ancestor more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid omega-1 hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables monooxygenase activity	NAS Non-traceable Author Statement more info	PubMed
enables oxidoreductase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables steroid hydroxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in epoxygenase P450 pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in monoterpenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic catabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome P450 2C6

Names: cytochrome P450 PB1; cytochrome P450, subfamily IIC6

NP_001013926.2

EC 1.14.14.1

XP_038964917.1

EC 1.14.14.1

XP_038964931.2

EC 1.14.14.1

XP_038964940.1

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013904.2 → NP_001013926.2 cytochrome P450 2C6

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P05178

UniProtKB/TrEMBL

F1LR47

Related

ENSRNOP00000051625.5, ENSRNOT00000054742.6

Conserved Domains (1) summary

cd20665
Location:61 → 485

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

247879058..247916804

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109003.2 → XP_038964931.2 cytochrome P450 2C6 isoform X1
XM_039108989.2 → XP_038964917.1 cytochrome P450 2C6 isoform X2

UniProtKB/TrEMBL

A0A1B0GWV3, A0A8I6ARV0

Related

ENSRNOP00000094011.1

Conserved Domains (1) summary

cd20665
Location:23 → 447

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s
XM_039109012.1 → XP_038964940.1 cytochrome P450 2C6 isoform X3

UniProtKB/TrEMBL

Q498S4

Conserved Domains (1) summary

cd20665
Location:1 → 350

CYP2C-like; cytochrome P450 family 2, subfamily C, and similar cytochrome P450s