Dspp dentin sialophosphoprotein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dsppprovided by RGD
Official Full Name: dentin sialophosphoproteinprovided by RGD
Primary source: RGD:2525
See related: Ensembl:ENSRNOG00000002168 AllianceGenome:RGD:2525
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dsp; RDSP2
Summary: Enables collagen binding activity. Involved in several processes, including animal organ development; cellular response to dexamethasone stimulus; and odontoblast differentiation. Acts upstream of or within positive regulation of calcium ion import. Located in several cellular components, including collagen-containing extracellular matrix; nucleus; and plasma membrane. Biomarker of osteoporosis. Human ortholog(s) of this gene implicated in dentinogenesis imperfecta. Orthologous to human DSPP (dentin sialophosphoprotein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (5870232..5876339, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (5565562..5571669, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (6926972..6933079, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of DSPP promotes the proliferation and migration of astrocytes.
Title: Overexpression of DSPP promotes the proliferation and migration of astrocytes.
the effect of leptin on Dentin sialophosphoprotein expression in human dental pulp
Title: Leptin promotes dentin sialophosphoprotein expression in human dental pulp.
NFIC regulates DSPP and E-cadherin via control of KLF4 during dentinogenesis.
Title: Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis.
Lef1 expression precedes Dspp expression without exception in both primary and reparative dentinogeneses. results suggest Lef1 might play a key role in odontoblast differentiation through regulating Dspp expression.
Title: Lymphoid enhancer-binding factor 1 expression precedes dentin sialophosphoprotein expression during rat odontoblast differentiation and regeneration.
The mineralization induction capabilities of bone sialoprotein (BSP), osteopontin (OPN), and the calcium-binding subdomain of dentin sialophosphoprotein, dentin phosphoprotein (DPP), are directly compared on a biomimetic collagen substrate.
Title: Mineralization induction effects of osteopontin, bone sialoprotein, and dentin phosphoprotein on a biomimetic collagen substrate.
Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells.
Title: Dentin phosphoprotein binds annexin 2 and is involved in calcium transport in rat kidney ureteric bud cells.
The expression of DSP/PP in hair follicles is the first demonstration that major mineralization proteins likely may also contribute to soft tissue development.
Title: Expression of mineralized tissue associated proteins: dentin sialoprotein and phosphophoryn in rodent hair follicles.
The aim of this study was to verify the expression, distribution and role of Rho GTPases in ameloblasts and odontoblasts during tooth development in correlation with actin and tubulin arrangements and amelogenin and dentin sialophosphoprotein expression.
Title: GTPases RhoA and Rac1 are important for amelogenin and DSPP expression during differentiation of ameloblasts and odontoblasts.
Dynamic processing of the Dspp protein is reported.
Title: Dynamic processing of recombinant dentin sialoprotein-phosphophoryn protein.
Dentin sialoprotein has characteristic temporal and spatial expression patterns within odontogenic tissues during dentin mineralization.
Title: Differential expression patterns of the dentin matrix proteins during mineralized tissue formation.

Submit: New GeneRIF Correction See all GeneRIFs (13)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within S-shaped body morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ameloblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within amelogenesis	ISO Inferred from Sequence Orthology more info
involved_in biomineral tissue development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cellular response to cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hormone stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within connective tissue development	ISO Inferred from Sequence Orthology more info
involved_in dentinogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dentinogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within dentinogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression involved in extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in hair follicle maturation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mandibular condyle articular cartilage development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mandibular condyle articular cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of bone development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of growth plate cartilage chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in odontoblast differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in odontoblast differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within odontoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of enamel mineralization	ISO Inferred from Sequence Orthology more info
involved_in regulation of odontoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to transforming growth factor beta	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dentin sialophosphoprotein

Names: Dentin sialoprotein; Dentine sialoprotein; dentin sailophosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012790.3 → NP_036922.3 dentin sialophosphoprotein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

E9PTW3

Related

ENSRNOP00000002946.5, ENSRNOT00000002946.8

Conserved Domains (1) summary

NF033849
Location:199 → 469

ser_rich_anae_1; serine-rich protein