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    Atp9a ATPase phospholipid transporting 9A (putative) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 84011, updated on 2-May-2024

    Summary

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    Official Symbol
    Atp9aprovided by RGD
    Official Full Name
    ATPase phospholipid transporting 9A (putative)provided by RGD
    Primary source
    RGD:621421
    See related
    Ensembl:ENSRNOG00000049484 AllianceGenome:RGD:621421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protease binding activity. Predicted to be involved in negative regulation of exosomal secretion; regulation of endocytic recycling; and regulation of retrograde transport, endosome to Golgi. Predicted to be located in several cellular components, including endosome membrane; perinuclear region of cytoplasm; and trans-Golgi network membrane. Orthologous to human ATP9A (ATPase phospholipid transporting 9A (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Brain (RPKM 642.2), Muscle (RPKM 444.4) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Atp9a in Genome Data Viewer
    Location:
    3q42
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (177779203..177886431, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (157360354..157467628, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (165405588..165511104, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554533 Neighboring gene nuclear factor of activated T-cells 2 Neighboring gene uncharacterized LOC102554478 Neighboring gene spalt-like transcription factor 4 Neighboring gene guanine nucleotide exchange factor subunit RIC1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION. Ansari IU, et al. J Biol Chem, 2015 Sep 18. PMID 26240149, Free PMC Article
    2. Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Halleck MS, et al. Genome Res, 1998 Apr. PMID 9548971
    3. Proton myo-inositol cotransporter is a novel γ-secretase associated protein that regulates Aβ production without affecting Notch cleavage. Teranishi Y, et al. FEBS J, 2015 Sep. PMID 26094765
    4. Differential expression of putative transbilayer amphipath transporters. Halleck MS, et al. Physiol Genomics, 1999 Nov 11. PMID 11015572
    5. ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner. Takatsu H, et al. J Biol Chem, 2011 Nov 4. PMID 21914794, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the predominant P4 ATPases in pure pancreatic beta cells and human and rat pancreatic islets were ATP8B1, ATP8B2, and ATP9A. ATP8B1 and CDC50A were highly concentrated in ISG
      Title: Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled intramembrane lipid transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of retrograde transport, endosome to Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable phospholipid-transporting ATPase IIA
    Names
    ATPase, class II, type 9A
    NP_001413946.1
    NP_001413947.1
    NP_001413948.1
    XP_038962655.2
    XP_038962659.1
    XP_063140758.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427017.1 → NP_001413946.1  probable phospholipid-transporting ATPase IIA isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6ACQ2

    2. NM_001427018.1 → NP_001413947.1  probable phospholipid-transporting ATPase IIA isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A913

    3. NM_001427019.1 → NP_001413948.1  probable phospholipid-transporting ATPase IIA isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      M0R6E0

    4. NM_032064.1 → NP_114453.1  probable phospholipid-transporting ATPase IIA isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      177779203..177886431 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106727.2 → XP_038962655.2  probable phospholipid-transporting ATPase IIA isoform X1

      UniProtKB/TrEMBL
      A0A8I6GI47

    2. XM_039106731.2 → XP_038962659.1  probable phospholipid-transporting ATPase IIA isoform X2

      UniProtKB/TrEMBL
      M0R6E0
      Related
      ENSRNOP00000064988.3
      Conserved Domains (2) summary
      cd07541
      Location:33 → 945
      P-type_ATPase_APLT_Neo1-like; Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B
      pfam13246
      Location:442 → 549
      Cation_ATPase; Cation transport ATPase (P-type)

    3. XM_063284688.1 → XP_063140758.1  probable phospholipid-transporting ATPase IIA isoform X3

      UniProtKB/TrEMBL
      M0R6E0
    Nucleotide Protein Strain
    Heading Accession and Version

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