Xylt1 xylosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Xylt1provided by RGD
Official Full Name: xylosyltransferase 1provided by RGD
Primary source: RGD:620093
See related: Ensembl:ENSRNOG00000056658 AllianceGenome:RGD:620093
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Xt1; XYLT-1
Summary: Predicted to enable protein xylosyltransferase activity. Involved in negative regulation of axon regeneration; proteoglycan biosynthetic process; and response to interleukin-1. Predicted to be located in Golgi cis cisterna; Golgi membrane; and extracellular space. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in Desbuquois dysplasia; pseudoxanthoma elasticum; and type 1 diabetes mellitus. Orthologous to human XYLT1 (xylosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 51.6), Thymus (RPKM 47.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (181078222..181361047)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (171643925..171929774)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (186939698..187264758)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells.
Title: Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.
Xylosyltransferase and heparanase expression is upregulated in adriamycin nephropathy.
Title: [Gene expressions of xylosyltransferase and heparanase in renal tissue of rat with adriamycin nephropathy and relevance for proteinuria].
Expression of xylosyltransferase I (XT-I) gene initiating proteoglycan-glycosaminoglycan chain synthesis was significantly reduced in antigen-induced arthritis rat cartilage and was associated with a decrease in proteoglycan synthesis.
Title: Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF397864 (e-PCR)
- UniSTS:246336

D1Rat357 (e-PCR), detects polymorphism
- UniSTS:227150

RH144569 (e-PCR)
- UniSTS:233814

d1rat237 (e-PCR)
- UniSTS:121475

D1Rat434 (e-PCR), detects polymorphism
- UniSTS:227217

D1Rat205 (e-PCR), detects polymorphism
- UniSTS:227059

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein xylosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein xylosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein xylosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in chondroitin sulfate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycosaminoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in heparan sulfate proteoglycan biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in heparan sulfate proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ossification involved in bone maturation	ISO Inferred from Sequence Orthology more info
involved_in ossification involved in bone maturation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteoglycan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in proteoglycan biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to interleukin-1	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi cis cisterna	ISO Inferred from Sequence Orthology more info
located_in Golgi cis cisterna	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: xylosyltransferase 1

Names: peptide O-xylosyltransferase 1; xylosyltransferase I

NP_071631.1

EC 2.4.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022295.3 → NP_071631.1 xylosyltransferase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q9EPI1

UniProtKB/TrEMBL

A0A0G2K6K1

Related

ENSRNOP00000073845.2, ENSRNOT00000082738.2

Conserved Domains (2) summary

pfam12529
Location:609 → 789

Xylo_C; Xylosyltransferase C terminal

cl27418
Location:324 → 576

Branch; Core-2/I-Branching enzyme