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    Tspyl1 TSPY-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29544, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Tspyl1provided by RGD
    Official Full Name
    TSPY-like 1provided by RGD
    Primary source
    RGD:1307726
    See related
    AllianceGenome:RGD:1307726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Al8; Tspyl
    Summary
    Predicted to enable chromatin binding activity; enzyme binding activity; and histone binding activity. Predicted to be involved in nucleosome assembly. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromatin and nucleus. Human ortholog(s) of this gene implicated in gonadal dysgenesis and sudden infant death syndrome. Orthologous to several human genes including TSPYL1 (TSPY like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Tspyl1 in Genome Data Viewer
    Location:
    20q12
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (39637035..39639594)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (38082003..38084562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (41083317..41085876)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene double homeobox protein 4-like protein 4 Neighboring gene uncharacterized LOC108349077 Neighboring gene TSPY-like 4 Neighboring gene 5'-nucleotidase domain containing 1 Neighboring gene collagen type X alpha 1 chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping of sudden infant death with dysgenesis of the testes syndrome (SIDDT) by a SNP genome scan and identification of TSPYL loss of function. Puffenberger EG, et al. Proc Natl Acad Sci U S A, 2004 Aug 10. PMID 15273283, Free PMC Article
    2. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific Y-encoded-like protein 1
    Names
    testis-specific protein, Y-encoded-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013033.1 → NP_001013051.1  testis-specific Y-encoded-like protein 1

      See identical proteins and their annotated locations for NP_001013051.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081955
      UniProtKB/TrEMBL
      Q642B1
      Conserved Domains (1) summary
      pfam00956
      Location:170 → 351
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      39637035..39639594
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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