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    Ppp2r5c protein phosphatase 2, regulatory subunit B', gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691318, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Ppp2r5cprovided by RGD
    Official Full Name
    protein phosphatase 2, regulatory subunit B', gammaprovided by RGD
    Primary source
    RGD:1585097
    See related
    Ensembl:ENSRNOG00000004973 AllianceGenome:RGD:1585097
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable peptidase activity and protein phosphatase activator activity. Predicted to be involved in negative regulation of cell population proliferation; protein dephosphorylation; and signal transduction by p53 class mediator. Predicted to act upstream of or within proteasome-mediated ubiquitin-dependent protein catabolic process and protein processing. Predicted to be located in Golgi apparatus; chromosome, centromeric region; and nucleoplasm. Predicted to be integral component of membrane. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Orthologous to human PPP2R5C (protein phosphatase 2 regulatory subunit B'gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 299.9), Heart (RPKM 229.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppp2r5c in Genome Data Viewer
    Location:
    6q32
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (135282947..135419591)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (129461689..129598344)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (134804128..134941912)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546759 Neighboring gene ribosomal protein S21, pseudogene 4 Neighboring gene uncharacterized LOC102547242 Neighboring gene uncharacterized LOC120103624 Neighboring gene dynein cytoplasmic 1 heavy chain 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes. Glaser ND, et al. Am J Physiol Heart Circ Physiol, 2006 Sep. PMID 16603688, Free PMC Article
    2. Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes. Bhasin N, et al. Am J Physiol Heart Circ Physiol, 2007 Jul. PMID 17416611
    3. Structure of the protein phosphatase 2A holoenzyme. Xu Y, et al. Cell, 2006 Dec 15. PMID 17174897
    4. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2. Terentyev D, et al. Circ Res, 2009 Feb 27. PMID 19131648, Free PMC Article
    5. PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation. Tang Z, et al. Dev Cell, 2006 May. PMID 16580887

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.
      Title: miR-1 overexpression enhances Ca(2+) release and promotes cardiac arrhythmogenesis by targeting PP2A regulatory subunit B56alpha and causing CaMKII-dependent hyperphosphorylation of RyR2.
    2. These new data implicate ankyrin-B as a critical targeting component for PP2A in heart and identify a new class of signaling proteins targeted by ankyrin polypeptides.
      Title: Molecular basis for PP2A regulatory subunit B56alpha targeting in cardiomyocytes.
    3. In an established model of sustained JNK activation, a 70% decrease in expression of the targeting subunit of PP2A, B56alpha, was observed in either neonatal or adult cardiomyocytes.
      Title: JNK activation decreases PP2A regulatory subunit B56alpha expression and mRNA stability and increases AUF1 expression in cardiomyocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191112.2 → NP_001178041.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AAX1, D4A1A5
      Related
      ENSRNOP00000007595.5, ENSRNOT00000007595.8
      Conserved Domains (1) summary
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    2. NM_001415125.1 → NP_001402054.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    3. NM_001415126.1 → NP_001402055.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I5ZRT0
      Related
      ENSRNOP00000080856.1, ENSRNOT00000104738.1

    4. NM_001415127.1 → NP_001402056.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6AKJ3
      Related
      ENSRNOP00000089250.1, ENSRNOT00000095073.1

    5. NM_001415128.1 → NP_001402057.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A0C3
      Related
      ENSRNOP00000085964.1, ENSRNOT00000113176.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      135282947..135419591
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262522.1 → XP_063118592.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X2

    2. XM_039112971.2 → XP_038968899.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1

      UniProtKB/TrEMBL
      A0A0G2JZD1, A0A8I5ZRC2
      Related
      ENSRNOP00000079611.1
      Conserved Domains (1) summary
      pfam01603
      Location:88 → 491
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    3. XM_008764962.4 → XP_008763184.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3

      UniProtKB/TrEMBL
      A0A0G2JZD1
      Conserved Domains (2) summary
      PLN00122
      Location:396 → 496
      PLN00122; serine/threonine protein phosphatase 2A; Provisional
      pfam01603
      Location:88 → 491
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    4. XM_063262527.1 → XP_063118597.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

    5. XM_039112973.2 → XP_038968901.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X7

      UniProtKB/TrEMBL
      A0A8I6AAX1
      Conserved Domains (1) summary
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    6. XM_063262524.1 → XP_063118594.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X5

    7. XM_039112974.2 → XP_038968902.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X8

      UniProtKB/TrEMBL
      A0A0G2JZD1
      Conserved Domains (1) summary
      pfam01603
      Location:34 → 437
      B56; Protein phosphatase 2A regulatory B subunit (B56 family)

    8. XM_063262525.1 → XP_063118595.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X6

    9. XM_063262523.1 → XP_063118593.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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