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    Wars1 tryptophanyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314442, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Wars1provided by RGD
    Official Full Name
    tryptophanyl-tRNA synthetase 1provided by RGD
    Primary source
    RGD:1308278
    See related
    Ensembl:ENSRNOG00000004359 AllianceGenome:RGD:1308278
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Wars
    Summary
    Predicted to enable several functions, including kinase inhibitor activity; protein homodimerization activity; and tryptophan-tRNA ligase activity. Predicted to be involved in several processes, including regulation of angiogenesis; regulation of protein modification process; and tryptophanyl-tRNA aminoacylation. Predicted to be located in cytosol and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 100.1), Brain (RPKM 74.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wars1 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (133540463..133571645, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (127776088..127807273, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (132771026..132802262, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479257 Neighboring gene microRNA 345 Neighboring gene solute carrier family 25, member 47 Neighboring gene WD repeat domain 25 Neighboring gene brain-enriched guanylate kinase-associated

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A recurrent WARS mutation is a novel cause of autosomal dominant distal hereditary motor neuropathy. Tsai PC, et al. Brain, 2017 May 1. PMID 28369220, Free PMC Article
    2. A human aminoacyl-tRNA synthetase as a regulator of angiogenesis. Wakasugi K, et al. Proc Natl Acad Sci U S A, 2002 Jan 8. PMID 11773626, Free PMC Article
    3. A fragment of human TrpRS as a potent antagonist of ocular angiogenesis. Otani A, et al. Proc Natl Acad Sci U S A, 2002 Jan 8. PMID 11773625, Free PMC Article
    4. Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases. Wakasugi K. FEBS Lett, 2010 Jan 4. PMID 19941862
    5. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling. Sajish M, et al. Nat Chem Biol, 2012 Apr 15. PMID 22504299, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tryptophan-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tryptophan-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tryptophan-tRNA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan--tRNA ligase, cytoplasmic
    Names
    trpRS
    tryptophanyl-tRNA synthetase, cytoplasmic
    NP_001013188.2
    XP_038968331.1
    XP_038968332.1
    XP_063118081.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013170.2 → NP_001013188.2  tryptophan--tRNA ligase, cytoplasmic

      Status: VALIDATED

      Source sequence(s)
      AY724504
      UniProtKB/TrEMBL
      A6KBI0
      Conserved Domains (3) summary
      PLN02486
      Location:89 → 470
      PLN02486; aminoacyl-tRNA ligase
      TIGR00233
      Location:158 → 467
      trpS; tryptophanyl-tRNA synthetase
      pfam00458
      Location:16 → 68
      WHEP-TRS; WHEP-TRS domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      133540463..133571645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112404.2 → XP_038968332.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A6KBI0, F8WFH8
      Conserved Domains (2) summary
      PLN02486
      Location:89 → 470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:16 → 65
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

    2. XM_039112403.2 → XP_038968331.1  tryptophan--tRNA ligase, cytoplasmic isoform X1

      UniProtKB/TrEMBL
      A6KBI0, F8WFH8
      Related
      ENSRNOP00000049063.3
      Conserved Domains (2) summary
      PLN02486
      Location:89 → 470
      PLN02486; aminoacyl-tRNA ligase
      cd00936
      Location:16 → 65
      WEPRS_RNA; WEPRS_RNA binding domain. This short RNA-binding domain is found in several higher eukaryote aminoacyl-tRNA synthetases (aaRSs). It is found in multiple copies in eukaryotic bifunctional glutamyl-prolyl-tRNA synthetases (EPRS) in a region that separates ...

    3. XM_063262011.1 → XP_063118081.1  tryptophan--tRNA ligase, cytoplasmic isoform X2

      UniProtKB/TrEMBL
      A6KBI0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7B0.2 GenPept UniProtKB/Swiss-Prot:Q6P7B0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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