U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gde1 glycerophosphodiester phosphodiesterase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60418, updated on 2-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gde1provided by RGD
    Official Full Name
    glycerophosphodiester phosphodiesterase 1provided by RGD
    Primary source
    RGD:621788
    See related
    Ensembl:ENSRNOG00000050445 AllianceGenome:RGD:621788
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mir16
    Summary
    Predicted to enable glycerophosphodiester phosphodiesterase activity; glycerophosphoinositol glycerophosphodiesterase activity; and lysophospholipase activity. Predicted to be involved in N-acylethanolamine metabolic process; ethanolamine metabolic process; and phospholipid metabolic process. Is integral component of membrane. Orthologous to human GDE1 (glycerophosphodiester phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 1262.0), Kidney (RPKM 834.7) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gde1 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (182451182..182466569, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (173016984..173032396, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (188367550..188407125, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-like protein FUBI-like Neighboring gene transmembrane channel-like 7 Neighboring gene uncharacterized LOC120099917 Neighboring gene transmembrane channel-like 5 Neighboring gene centriolar coiled-coil protein 110 Neighboring gene VPS35 endosomal protein sorting factor like Neighboring gene small nucleolar RNA SNORA24

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors. Zheng B, et al. Proc Natl Acad Sci U S A, 2003 Feb 18. PMID 12576545, Free PMC Article
    2. Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis. Tsuboi K, et al. Biochim Biophys Acta, 2015 May. PMID 25596343
    3. MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. Zheng B, et al. Proc Natl Acad Sci U S A, 2000 Apr 11. PMID 10760272, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables glycerophosphodiester phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerophosphodiester phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerophosphodiester phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycerophosphoinositol glycerophosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycerophosphoinositol glycerophosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables lysophospholipase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lysophospholipase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in N-acylethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within N-acylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acylethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in N-acylethanolamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ethanolamine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ethanolamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanolamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phospholipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycerophosphodiester phosphodiesterase 1
    Names
    glycerophosphoinositol glycerophosphodiesterase GDE1
    lysophospholipase D GDE1
    membrane-interacting protein of RGS16
    NP_116004.2
    XP_063128560.1
    XP_063128562.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032615.2 → NP_116004.2  glycerophosphodiester phosphodiesterase 1

      See identical proteins and their annotated locations for NP_116004.2

      Status: PROVISIONAL

      Source sequence(s)
      BC070897
      UniProtKB/Swiss-Prot
      Q6IRJ6, Q9JL55
      UniProtKB/TrEMBL
      A6I8I2, M0R5Q9
      Related
      ENSRNOP00000064735.2, ENSRNOT00000073233.3
      Conserved Domains (1) summary
      cd08573
      Location:68 → 323
      GDPD_GDE1; Glycerophosphodiester phosphodiesterase domain of mammalian glycerophosphodiester phosphodiesterase GDE1 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      182451182..182466569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272492.1 → XP_063128562.1  glycerophosphodiester phosphodiesterase 1 isoform X1

    2. XM_063272490.1 → XP_063128560.1  glycerophosphodiester phosphodiesterase 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JL55.2 GenPept UniProtKB/Swiss-Prot:Q9JL55

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous