Syt17 synaptotagmin 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Syt17provided by RGD
Official Full Name: synaptotagmin 17provided by RGD
Primary source: RGD:708576
See related: Ensembl:ENSRNOG00000017136 AllianceGenome:RGD:708576
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bk
Summary: Predicted to enable several functions, including calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Predicted to be involved in several processes, including cellular response to calcium ion; positive regulation of dendrite extension; and regulation of secretion by cell. Predicted to be located in trans-Golgi network. Predicted to be active in exocytic vesicle and plasma membrane. Orthologous to human SYT17 (synaptotagmin 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 51.7), Kidney (RPKM 45.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (182129491..182195827, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (172695275..172761906, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (188034614..188101590, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Induction of both B/K protein expression and ER stress response in hippocampus of a rat kainate seizure model and ER stress-induced expression of B/K strongly suggest the possible role of B/K protein in epileptogenesis or epilepsy-induced neuronal damage
Title: Expression of B/K protein in the hippocampus of kainate-induced rat seizure model.
B/K protein is closely associated with cell death in proximal tubules, which are vulnerable to ischemia-reperfusion injury in the kidney
Title: Differential regulation of B/K protein expression in proximal and distal tubules of rat kidneys with ischemia-reperfusion injury.

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General gene information

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Markers

AU028251 (e-PCR)
- UniSTS:112508

AU049382 (e-PCR)
- UniSTS:145829

D1Mgh26 (e-PCR)
- UniSTS:239283

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylserine binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium-ion regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of dendrite extension	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic neurotransmitter receptor internalization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptotagmin-17

Names: B/K protein; brain and kidney protein; protein B/K; synaptotagmin XVII; sytXVII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138849.2 → NP_620204.1 synaptotagmin-17

See identical proteins and their annotated locations for NP_620204.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q62807

Related

ENSRNOP00000023090.4, ENSRNOT00000023090.5

Conserved Domains (2) summary

cd08390
Location:186 → 314

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:323 → 457

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

182129491..182195827 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017588770.3 → XP_017444259.2 synaptotagmin-17 isoform X3

UniProtKB/TrEMBL

A6I8H0

Conserved Domains (2) summary

cd08390
Location:125 → 253

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:262 → 396

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
XM_039092421.2 → XP_038948349.1 synaptotagmin-17 isoform X2

UniProtKB/TrEMBL

A0A0U1RRV6

Related

ENSRNOP00000075827.2

Conserved Domains (2) summary

cd08390
Location:180 → 308

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:317 → 451

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
XM_063278991.1 → XP_063135061.1 synaptotagmin-17 isoform X3
XM_006230104.2 → XP_006230166.1 synaptotagmin-17 isoform X1

UniProtKB/TrEMBL

A0A0G2K9H6

Related

ENSRNOP00000075000.1, ENSRNOT00000078825.2

Conserved Domains (2) summary

cd08390
Location:182 → 310

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:319 → 453

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
XM_017588772.2 → XP_017444261.1 synaptotagmin-17 isoform X3

UniProtKB/TrEMBL

A6I8H0

Conserved Domains (2) summary

cd08390
Location:125 → 253

C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17

cd08410
Location:262 → 396

C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17