Tacstd2 tumor-associated calcium signal transducer 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tacstd2provided by MGI
Official Full Name: tumor-associated calcium signal transducer 2provided by MGI
Primary source: MGI:MGI:1861606
See related: Ensembl:ENSMUSG00000051397 AllianceGenome:MGI:1861606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly97; EGP-1; TROP2; GA733-1
Summary: Involved in several processes, including negative regulation of branching involved in ureteric bud morphogenesis; negative regulation of cellular component organization; and negative regulation of substrate adhesion-dependent cell spreading. Acts upstream of or within positive regulation of stem cell differentiation; regulation of epithelial cell proliferation; and ureteric bud morphogenesis. Located in several cellular components, including basal plasma membrane; extracellular space; and lateral plasma membrane. Is expressed in alimentary system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in corneal dystrophy and gelatinous drop-like corneal dystrophy. Orthologous to human TACSTD2 (tumor associated calcium signal transducer 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 30.88 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (67511043..67512806, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (67534059..67535822, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa.
Title: Trop2 is upregulated in the transition to dysplasia in the metaplastic gastric mucosa.
studies have begun to identify the mechanisms underlying TROP2's functions, including regulated intramembrane proteolysis or specific interactions with integrin b1 and claudin proteins.
Title: Trop2: from development to disease.
Trop2 is a regulator of self-renewal, proliferation, and transformation
Title: Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.
TROP2 modulates the interaction between the cells and matrix and regulates the formation of the ureteric duct by suppressing branching from the trunk during kidney development.
Title: TROP2 expressed in the trunk of the ureteric duct regulates branching morphogenesis during kidney development.
these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.
Title: Loss of Trop2 promotes carcinogenesis and features of epithelial to mesenchymal transition in squamous cell carcinoma.
In human and mouse, Trop2 is highly expressed at both the transcript and protein levels on several essential normal tissues.
Title: Expression of Trop2 cell surface glycoprotein in normal and tumor tissues: potential implications as a cancer therapeutic target.
Study also provides the first indication of a molecular signaling pathway activated by Trop2 which has important implications for cancer cell growth and survival.
Title: Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway.
Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.
Title: Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:487866

C80403 (e-PCR)
- UniSTS:179388

NoName (e-PCR)
- UniSTS:235463

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in negative regulation of branching involved in ureteric bud morphogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell motility	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of epithelial cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ruffle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stress fiber assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of stem cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of stem cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of epithelial cell proliferation	IEP Inferred from Expression Pattern more info	PubMed
involved_in ureteric bud morphogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor-associated calcium signal transducer 2

Names: cell surface glycoprotein Trop-2; lymphocyte antigen 97; tunor-associated calcium signal transducer 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.