Kcnab3 potassium voltage-gated channel, shaker-related subfamily, beta member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kcnab3provided by MGI
Official Full Name: potassium voltage-gated channel, shaker-related subfamily, beta member 3provided by MGI
Primary source: MGI:MGI:1336208
See related: Ensembl:ENSMUSG00000018470 AllianceGenome:MGI:1336208
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kcnab4; mKv(beta)4; C330022D06Rik
Summary: Predicted to enable aldo-keto reductase (NADP) activity; potassium channel regulator activity; and transmembrane transporter binding activity. Predicted to be involved in regulation of potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Predicted to be located in cytoplasm. Predicted to be integral component of membrane. Predicted to be part of voltage-gated potassium channel complex. Is expressed in central nervous system; eye; heart; intestine; and male reproductive gland or organ. Orthologous to human KCNAB3 (potassium voltage-gated channel subfamily A regulatory beta subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 22.4), frontal lobe adult (RPKM 21.7) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.51 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69217084..69223867)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69326258..69333041)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

D11Ertd172e (e-PCR), detects polymorphism
- UniSTS:167044

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables potassium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-3

Names: K(+) channel subunit beta-3; kv-beta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010599.4 → NP_034729.3 voltage-gated potassium channel subunit beta-3

See identical proteins and their annotated locations for NP_034729.3

Status: VALIDATED

Source sequence(s)

AK049316, AK083134

Consensus CDS

CCDS24890.1

UniProtKB/TrEMBL

Q8BQX9, Q8C439, Q8C7S9, Q8VD73

Related

ENSMUSP00000018614.3, ENSMUST00000018614.3

Conserved Domains (2) summary

cd06660
Location:80 → 395

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

TIGR01293
Location:80 → 396

Kv_beta; voltage-dependent potassium channel beta subunit, animal