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    Dpm3 dolichyl-phosphate mannosyltransferase subunit 3, regulatory [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502017, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Dpm3provided by RGD
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 3, regulatoryprovided by RGD
    Primary source
    RGD:1561807
    See related
    Ensembl:ENSRNOG00000065280 AllianceGenome:RGD:1561807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561807
    Summary
    Predicted to enable enzyme activator activity. Predicted to be involved in GPI anchor biosynthetic process and regulation of protein stability. Predicted to be located in endoplasmic reticulum. Predicted to be part of dolichol-phosphate-mannose synthase complex. Predicted to be integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation and muscular dystrophy-dystroglycanopathy. Orthologous to human DPM3 (dolichyl-phosphate mannosyltransferase subunit 3, regulatory). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 203.0), Kidney (RPKM 187.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpm3 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176974290..176974805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174676532..174677047)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188583664..188584179)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mucin 1, cell surface associated Neighboring gene tripartite motif-containing 46 Neighboring gene keratinocyte associated protein 2 Neighboring gene solute carrier family 50 member 1 Neighboring gene ephrin A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human dolichol-phosphate-mannose synthase consists of three subunits, DPM1, DPM2 and DPM3. Maeda Y, et al. EMBO J, 2000 Jun 1. PMID 10835346, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of dolichol-phosphate-mannose synthase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dolichol-phosphate-mannose synthase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dolichol-phosphate mannosyltransferase subunit 3
    Names
    dolichyl-phosphate mannosyltransferase polypeptide 3
    NP_001102801.1
    XP_038958890.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109331.2 → NP_001102801.1  dolichol-phosphate mannosyltransferase subunit 3

      See identical proteins and their annotated locations for NP_001102801.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6J6D9, D3ZIJ5
      Related
      ENSRNOP00000077865.1, ENSRNOT00000098256.1
      Conserved Domains (1) summary
      pfam08285
      Location:1 → 90
      DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176974290..176974805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102962.2 → XP_038958890.1  dolichol-phosphate mannosyltransferase subunit 3 isoform X1

      UniProtKB/TrEMBL
      A6J6D9, D3ZIJ5
      Conserved Domains (1) summary
      pfam08285
      Location:1 → 90
      DPM3; Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)
    Nucleotide Protein Strain
    Heading Accession and Version

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