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    Clk2 CDC-like kinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365842, updated on 2-May-2024

    Summary

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    Official Symbol
    Clk2provided by RGD
    Official Full Name
    CDC-like kinase 2provided by RGD
    Primary source
    RGD:1359711
    See related
    Ensembl:ENSRNOG00000020500 AllianceGenome:RGD:1359711
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in several processes, including negative regulation of gluconeogenesis; regulation of RNA splicing; and response to ionizing radiation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation; protein autophosphorylation; and response to retinoic acid. Predicted to be located in nuclear body. Orthologous to human CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 115.0), Kidney (RPKM 99.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Clk2 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (176868423..176880412)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (174570614..174582645)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (188476789..188488809)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 909 Neighboring gene farnesyl diphosphate synthase Neighboring gene pyruvate kinase L/R Neighboring gene hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 Neighboring gene microRNA 3541 Neighboring gene secretory carrier membrane protein 3 Neighboring gene endosomal transmembrane epsin interactor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cdc2-like kinase 2 is an insulin-regulated suppressor of hepatic gluconeogenesis. Rodgers JT, et al. Cell Metab, 2010 Jan. PMID 20074525, Free PMC Article
    2. The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation. Nayler O, et al. J Biol Chem, 1998 Dec 18. PMID 9852100
    3. Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation. Nam SY, et al. J Biol Chem, 2010 Oct 8. PMID 20682768, Free PMC Article
    4. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Duncan PI, et al. Exp Cell Res, 1998 Jun 15. PMID 9637771
    5. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Kulkarni P, et al. Proc Natl Acad Sci U S A, 2017 Mar 28. PMID 28289210, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-tyrosine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein kinase CLK2
    NP_001014276.1
    XP_008759408.1
    XP_008759409.1
    XP_008759411.1
    XP_008759412.1
    XP_008759413.1
    XP_008759414.1
    XP_038958690.1
    XP_063138326.1
    XP_063138327.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014254.1 → NP_001014276.1  dual specificity protein kinase CLK2

      See identical proteins and their annotated locations for NP_001014276.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083788
      UniProtKB/TrEMBL
      A0A0G2K5Q8, F1LNQ0, Q5XI98
      Related
      ENSRNOP00000073519.2, ENSRNOT00000085817.2
      Conserved Domains (1) summary
      cd14215
      Location:150 → 479
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      176868423..176880412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761186.4 → XP_008759408.1  dual specificity protein kinase CLK2 isoform X1

      See identical proteins and their annotated locations for XP_008759408.1

      Conserved Domains (2) summary
      smart00220
      Location:203 → 519
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:190 → 519
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    2. XM_008761187.4 → XP_008759409.1  dual specificity protein kinase CLK2 isoform X2

      Conserved Domains (2) summary
      smart00220
      Location:202 → 518
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:189 → 518
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    3. XM_039102762.2 → XP_038958690.1  dual specificity protein kinase CLK2 isoform X3

      Conserved Domains (1) summary
      cd14215
      Location:183 → 512
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    4. XM_008761189.4 → XP_008759411.1  dual specificity protein kinase CLK2 isoform X4

      Conserved Domains (2) summary
      smart00220
      Location:195 → 511
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:182 → 511
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    5. XM_008761190.4 → XP_008759412.1  dual specificity protein kinase CLK2 isoform X5

      Conserved Domains (2) summary
      smart00220
      Location:195 → 511
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:182 → 511
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    6. XM_008761191.4 → XP_008759413.1  dual specificity protein kinase CLK2 isoform X6

      Conserved Domains (2) summary
      smart00220
      Location:194 → 510
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:181 → 510
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    7. XM_008761192.4 → XP_008759414.1  dual specificity protein kinase CLK2 isoform X7

      Conserved Domains (2) summary
      smart00220
      Location:170 → 486
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14215
      Location:157 → 486
      PKc_CLK2; Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2

    8. XM_063282256.1 → XP_063138326.1  dual specificity protein kinase CLK2 isoform X8

      UniProtKB/TrEMBL
      A6J6C3

    9. XM_063282257.1 → XP_063138327.1  dual specificity protein kinase CLK2 isoform X9

    RNA

    1. XR_010063630.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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