Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cmtm2aprovided by RGD
Official Full Name: CKLF-like MARVEL transmembrane domain containing 2Aprovided by RGD
Primary source: RGD:1307501
See related: Ensembl:ENSRNOG00000025420 AllianceGenome:RGD:1307501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cklfsf1
Summary: Predicted to enable transcription corepressor activity. Predicted to act upstream of or within negative regulation of transcription, DNA-templated and regulation of testosterone biosynthetic process. Predicted to be located in cytoplasm and nucleus. Predicted to be integral component of membrane. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 3632.0) See more
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 19p14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (678154..685274)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (671719..678839)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (880024..887144)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Testosterone was associated with the expression of CMTM family during spermatogenesis, and CMTM2 and CMTM4 may take part in the spermatogenesis process.
Title: [Effect of testosterone on the expression of CMTM family of the male spermatogenesis suppression rats].
In vivo blockade of testicular alpha1-adrenergic receptors changed the stress-induced decrease of Nur77 and increase of Arr19 and Dax1 in Leydig cells.
Title: Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats.
These findings show ARR19 might play a crucial role in regulation of neuronal and testicular steroidogenesis in inflammatory diseases
Title: Bacterial lipopolysaccharide differently modulates steroidogenic enzymes gene expressions in the brain and testis in rats.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 2A

Names: chemokine-like factor super family 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.