Pla2g10 phospholipase A2, group X [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g10provided by RGD
Official Full Name: phospholipase A2, group Xprovided by RGD
Primary source: RGD:61935
See related: Ensembl:ENSRNOG00000003164 AllianceGenome:RGD:61935
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PLA2GX; sPLA2-X
Summary: Enables phospholipase A2 activity. Predicted to be involved in several processes, including cholesterol homeostasis; glycerophospholipid metabolic process; and positive regulation of lipid localization. Predicted to act upstream of or within several processes, including cellular response to leukemia inhibitory factor; erythrocyte maturation; and negative regulation of cytokine production involved in inflammatory response. Predicted to be located in acrosomal vesicle and extracellular space. Orthologous to human PLA2G10 (phospholipase A2 group X). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 81.5) and Kidney (RPKM 7.5) See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (2104927..2117998, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (1597761..1610822, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (1509732..1520970, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

group X secreted phospholipase A2 is expressed in neural cells and has neuritogenic action
Title: Neuronal expression and neuritogenic action of group X secreted phospholipase A2.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISO Inferred from Sequence Orthology more info
enables 1-alkyl-2-acetylglycerophosphocholine esterase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-dependent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipase A2 activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables phospholipase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IEA Inferred from Electronic Annotation more info
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in erythrocyte maturation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in fertilization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intestinal stem cell homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intestinal stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in low-density lipoprotein particle remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lysophospholipid transport	ISO Inferred from Sequence Orthology more info
involved_in macrophage activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within macrophage activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylglycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in platelet activating factor catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acrosome reaction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of arachidonic acid secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of arachidonic acid secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid storage	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in production of molecular mediator involved in inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within production of molecular mediator involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of macrophage activation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	IEA Inferred from Electronic Annotation more info
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: group 10 secretory phospholipase A2

Names: GX sPLA2; group X phospholipase A2; group X secretory phospholipase A2; phosphatidylcholine 2-acylhydrolase 10; phosphatidylcholine 2-acylhydrolase GX; phospholipase A2, group 10

NP_058872.2

EC 3.1.1.4

XP_038941644.1

EC 3.1.1.4

XP_038941647.1

EC 3.1.1.4

XP_038941649.1

EC 3.1.1.4

XP_038941650.1

EC 3.1.1.4

XP_038941652.1

EC 3.1.1.4

XP_038941654.1

EC 3.1.1.4

XP_038941659.1

EC 3.1.1.4

XP_063124872.1

EC 3.1.1.4

XP_063124873.1

EC 3.1.1.4

XP_063124874.1

EC 3.1.1.4

XP_063124875.1

EC 3.1.1.4

XP_063124877.1

EC 3.1.1.4

XP_063124878.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017176.3 → NP_058872.2 group 10 secretory phospholipase A2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9QZT3

UniProtKB/TrEMBL

A6K4E7, G3V6E2

Related

ENSRNOP00000004237.1, ENSRNOT00000004237.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

2104927..2117998 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268803.1 → XP_063124873.1 group 10 secretory phospholipase A2 isoform X1

UniProtKB/Swiss-Prot

Q9QZT3

UniProtKB/TrEMBL

A6K4E7, G3V6E2
XM_039085721.2 → XP_038941649.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_039085722.2 → XP_038941650.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_039085716.2 → XP_038941644.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_063268802.1 → XP_063124872.1 group 10 secretory phospholipase A2 isoform X1

UniProtKB/Swiss-Prot

Q9QZT3

UniProtKB/TrEMBL

A6K4E7, G3V6E2
XM_039085719.2 → XP_038941647.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_063268804.1 → XP_063124874.1 group 10 secretory phospholipase A2 isoform X2
XM_063268807.1 → XP_063124877.1 group 10 secretory phospholipase A2 isoform X2
XM_039085726.2 → XP_038941654.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_039085724.2 → XP_038941652.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_039085731.2 → XP_038941659.1 group 10 secretory phospholipase A2 isoform X2

Conserved Domains (1) summary

cd00125
Location:2 → 98

PLA2c; Phospholipase A2, a family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a metal-dependent ...
XM_063268808.1 → XP_063124878.1 group 10 secretory phospholipase A2 isoform X2
XM_063268805.1 → XP_063124875.1 group 10 secretory phospholipase A2 isoform X2