Crmp1 collapsin response mediator protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crmp1provided by RGD
Official Full Name: collapsin response mediator protein 1provided by RGD
Primary source: RGD:2407
See related: Ensembl:ENSRNOG00000004781 AllianceGenome:RGD:2407
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables filamin binding activity. Involved in neuron development. Located in cytoplasm and nucleus. Orthologous to human CRMP1 (collapsin response mediator protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 172.4) and Adrenal (RPKM 12.7) See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (77734675..77780916, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (73509933..73556192, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (78266931..78312777, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury.
Title: LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury.
Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
Title: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
High sugar but not high fat diet consumption induces hepatic metabolic disruption and up-regulation of mitochondrial fission-associated protein Drp1 in a model of moderate obesity.
Title: High sugar but not high fat diet consumption induces hepatic metabolic disruption and up-regulation of mitochondrial fission-associated protein Drp1 in a model of moderate obesity.
FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development.
Title: FEZ1 Forms Complexes with CRMP1 and DCC to Regulate Axon and Dendrite Development.
Data link the reduction in PMCA2 expression with perturbations in CRMP1 expression and death of spinal cord neurons, representing an additional mechanism underlying AMPA/kainate receptor-mediated excitotoxicity with relevance to neurodegeneration in EAE.
Title: Reduced expression of plasma membrane calcium ATPase 2 and collapsin response mediator protein 1 promotes death of spinal cord neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

d14mgh2 (e-PCR)
- UniSTS:120958

RH125184 (e-PCR)
- UniSTS:162006

RH129959 (e-PCR)
- UniSTS:213247

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables dihydropyrimidinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables filamin binding	IEA Inferred from Electronic Annotation more info
enables filamin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron development	IEP Inferred from Expression Pattern more info	PubMed
NOT involved_in pyrimidine nucleobase catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dihydropyrimidinase-related protein 1

Names: CRMP-1; DRP-1; inactive dihydropyrimidinase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001365151.1 → NP_001352080.1 dihydropyrimidinase-related protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

JAXUCZ010000014

UniProtKB/TrEMBL

A0A8I6A2Y7, A0A8I6ALU3

Related

ENSRNOP00000086765.1, ENSRNOT00000106933.1

Conserved Domains (1) summary

cd01314
Location:131 → 580

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...
NM_012932.3 → NP_037064.1 dihydropyrimidinase-related protein 1 isoform 2

See identical proteins and their annotated locations for NP_037064.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) is shorter with a distinct N-terminus compared to isoform 1.

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

P70546, Q62950

UniProtKB/TrEMBL

A0A8I6ANJ3

Related

ENSRNOP00000063671.1, ENSRNOT00000065334.3

Conserved Domains (1) summary

cd01314
Location:17 → 466

D-HYD; D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine ...