Itgb1bp2 integrin subunit beta 1 binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itgb1bp2provided by RGD
Official Full Name: integrin subunit beta 1 binding protein 2provided by RGD
Primary source: RGD:1565015
See related: Ensembl:ENSRNOG00000003596 AllianceGenome:RGD:1565015
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565015
Summary: Enables integrin binding activity. Predicted to be involved in integrin-mediated signaling pathway. Predicted to be active in Z disc. Orthologous to human ITGB1BP2 (integrin subunit beta 1 binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 820.5), Muscle (RPKM 562.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (70612118..70617158)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (66572537..66577174)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (71342770..71347623)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METH can produce cardiac damage and apoptosis by decreasing melusin.
Title: Methamphetamine produces cardiac damage and apoptosis by decreasing melusin.
Multiple hypertrophic stimuli regulate melusin expression predominately in the atria, which may represent a necessary initial step in early adaptive remodelling processes in left ventricular hypertrophy.
Title: Regulation of cardiac melusin gene expression by hypertrophic stimuli in the rat.
PI3K regulates the expression of genes essential for cardiac structure and Z-disc signaling, interacts with melusin, and is critical for Z-disc alignment
Title: Phosphoinositide 3-kinase (PI3K(p110alpha)) directly regulates key components of the Z-disc and cardiac structure.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin beta-1-binding protein 2

Names: melusin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108245.2 → NP_001101715.1 integrin beta-1-binding protein 2

See identical proteins and their annotated locations for NP_001101715.1

Status: VALIDATED

Source sequence(s)

FM116382, FM118664, JAXUCZ010000021

UniProtKB/TrEMBL

A6IQC2, D3ZW59

Related

ENSRNOP00000004888.4, ENSRNOT00000004888.8

Conserved Domains (2) summary

cd06488
Location:218 → 304

p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...

pfam04968
Location:3 → 64

CHORD; CHORD