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    Nsmce2 NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299957, updated on 2-May-2024

    Summary

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    Official Symbol
    Nsmce2provided by RGD
    Official Full Name
    NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligaseprovided by RGD
    Primary source
    RGD:1305156
    See related
    Ensembl:ENSRNOG00000003964 AllianceGenome:RGD:1305156
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305156
    Summary
    Predicted to enable SUMO ligase activity. Predicted to be involved in several processes, including DNA recombination; positive regulation of cell cycle process; and protein sumoylation. Predicted to be located in PML body and chromosome, telomeric region. Predicted to be part of Smc5-Smc6 complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 10. Orthologous to human NSMCE2 (NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 44.1), Adrenal (RPKM 36.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nsmce2 in Genome Data Viewer
    Location:
    7q33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (92825568..93071037)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (90936112..91173435)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (99677295..99900765)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene squalene epoxidase Neighboring gene WASH complex subunit 5 Neighboring gene interferon-induced transmembrane protein 2-like Neighboring gene uncharacterized LOC134479917 Neighboring gene uncharacterized LOC108351497 Neighboring gene hypothetical protein LOC690120

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SMC5 and MMS21 are required for chromosome cohesion and mitotic progression. Behlke-Steinert S, et al. Cell Cycle, 2009 Jul 15. PMID 19502785
    2. Human MMS21/NSE2 is a SUMO ligase required for DNA repair. Potts PR, et al. Mol Cell Biol, 2005 Aug. PMID 16055714, Free PMC Article
    3. Scc1 sumoylation by Mms21 promotes sister chromatid recombination through counteracting Wapl. Wu N, et al. Genes Dev, 2012 Jul 1. PMID 22751501, Free PMC Article
    4. Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks. Potts PR, et al. EMBO J, 2006 Jul 26. PMID 16810316, Free PMC Article
    5. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex. Taylor EM, et al. Mol Cell Biol, 2008 Feb. PMID 18086888, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114542

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SUMO transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SUMO transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT involved_in double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of maintenance of mitotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitotic metaphase/anaphase transition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in telomere maintenance via recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomere maintenance via recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in PML body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Smc5-Smc6 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Smc5-Smc6 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Smc5-Smc6 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Smc5-Smc6 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 SUMO-protein ligase NSE2
    Names
    E3 SUMO-protein transferase NSE2
    MMS21 homolog
    non-SMC element 2 homolog
    non-SMC element 2, MMS21 homolog
    non-structural maintenance of chromosomes element 2 homolog
    NP_001020047.1
    XP_006241733.1
    XP_017450247.1
    XP_017450249.1
    XP_038934723.1
    XP_038934726.1
    XP_038934727.1
    XP_063119329.1
    XP_063119330.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024876.1 → NP_001020047.1  E3 SUMO-protein ligase NSE2

      See identical proteins and their annotated locations for NP_001020047.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097477
      UniProtKB/Swiss-Prot
      Q4V8A0
      UniProtKB/TrEMBL
      A0A0G2JW49, A6HRM3
      Related
      ENSRNOP00000005376.4, ENSRNOT00000005376.6
      Conserved Domains (1) summary
      cd16651
      Location:167 → 236
      SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      92825568..93071037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039078795.2 → XP_038934723.1  E3 SUMO-protein ligase NSE2 isoform X3

      Conserved Domains (1) summary
      cd16651
      Location:133 → 202
      SPL-RING_NSE2; SPL-RING finger found in E3 SUMO-protein ligase NSE2 and similar proteins

    2. XM_017594758.3 → XP_017450247.1  E3 SUMO-protein ligase NSE2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A069, A6HRM2
      Related
      ENSRNOP00000085874.1
      Conserved Domains (1) summary
      pfam11789
      Location:182 → 242
      zf-Nse; Zinc-finger of the MIZ type in Nse subunit

    3. XM_063263259.1 → XP_063119329.1  E3 SUMO-protein ligase NSE2 isoform X2

    4. XM_039078798.2 → XP_038934726.1  E3 SUMO-protein ligase NSE2 isoform X6

      UniProtKB/TrEMBL
      A6HRM4

    5. XM_017594760.3 → XP_017450249.1  E3 SUMO-protein ligase NSE2 isoform X4

    6. XM_063263260.1 → XP_063119330.1  E3 SUMO-protein ligase NSE2 isoform X5

    7. XM_006241671.4 → XP_006241733.1  E3 SUMO-protein ligase NSE2 isoform X8

      UniProtKB/TrEMBL
      A0A8I6AS08
      Related
      ENSRNOP00000097544.1

    8. XM_039078799.2 → XP_038934727.1  E3 SUMO-protein ligase NSE2 isoform X7

    RNA

    1. XR_010052954.1 RNA Sequence

    2. XR_010052955.1 RNA Sequence

    3. XR_001838681.3 RNA Sequence

    4. XR_005486582.2 RNA Sequence

    5. XR_010052956.1 RNA Sequence

    6. XR_010052958.1 RNA Sequence

    7. XR_010052957.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8A0.1 GenPept UniProtKB/Swiss-Prot:Q4V8A0

    Gene LinkOut

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