Muc1 mucin 1, cell surface associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Muc1provided by RGD
Official Full Name: mucin 1, cell surface associatedprovided by RGD
Primary source: RGD:3122
See related: Ensembl:ENSRNOG00000020539 AllianceGenome:RGD:3122
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; p53 binding activity; and transcription coregulator activity. Involved in several processes, including cellular response to retinoic acid; female pregnancy; and response to hypoxia. Located in apical plasma membrane and cytoplasm. Used to study allergic rhinitis. Biomarker of allergic rhinitis; cholangiocarcinoma; and otitis media. Human ortholog(s) of this gene implicated in several diseases, including biliary tract benign neoplasm; dry eye syndrome; familial juvenile hyperuricemic nephropathy; mucinous adenocarcinoma; and pancreatic cancer (multiple). Orthologous to human MUC1 (mucin 1, cell surface associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 156.3), Kidney (RPKM 62.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (176933312..176938497)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (174635989..174640738)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (188543137..188547874)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MUC1 deficiency promotes nasal epithelial barrier dysfunction in subjects with allergic rhinitis.
Title: MUC1 deficiency promotes nasal epithelial barrier dysfunction in subjects with allergic rhinitis.
Mucin 1 distributes in the airway epithelial cells with ciliates and the expressional increase of Muc1 in lung may imply its functions on allergic inflammatory episodes
Title: Changes in mucin 1 expression in a rat model of allergic airway inflammation.
Increased lung MUC1 expression appears to be closely associated with impairment of alveolarization in a newborn model of hyperoxia-induced bronchopulmonary dysplasia.
Title: Changes in pulmonary tissue structure and KL-6/MUC1 expression in a newborn rat model of hyperoxia-induced bronchopulmonary dysplasia.
Muc1 expression was localized in the mammary gland ductus and branching ductus.
Title: [Expressions of Sca-1, CD24 and Muc1 in quiescent mammary glands of female rats].
The effect of geranylgeranylacetone on the expression of MUC1, MUC5AC, and MUC6 in ethanol-treated rats is reported.
Title: Gastric mucosal protection via enhancement of MUC5AC and MUC6 by geranylgeranylacetone.
Expression of MUC1 in 3Y1 cells activates the anti-apoptotic PI3K/Akt and Bcl-x(L) pathways.
Title: The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts.
We identified novel cell surface markers specific for hepatic progenitor/oval cells. Six are unique for the adult progenitors (CD133, claudin-7, cadherin 22, mucin-1, ros-1, Gabrp).
Title: Novel hepatic progenitor cell surface markers in the adult rat liver.

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General gene information

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Markers

RH94427 (e-PCR)
- UniSTS:119675

Muc1 (e-PCR), detects polymorphism
- UniSTS:527001

AU047994 (e-PCR)
- UniSTS:109978

Muc1 (e-PCR), detects polymorphism
- UniSTS:516859

Muc1 (e-PCR), detects polymorphism
- UniSTS:516860

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in in utero embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mucin-1

Names: Mucin1; mucin 1, transmembrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398538.1 → NP_001385467.1 mucin-1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

B2GV31, F1LMZ5

Related

ENSRNOP00000027850.5, ENSRNOT00000027850.8

Conserved Domains (2) summary

smart00200
Location:436 → 552

SEA; Domain found in sea urchin sperm protein, enterokinase, agrin

PHA03307
Location:32 → 300

PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

176933312..176938497

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281292.1 → XP_063137362.1 mucin-1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_012602.1: Suppressed sequence

Description

NM_012602.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: MUC1 (GeneID:4582).