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    Bcas1 brain enriched myelin associated protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 246755, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Bcas1provided by RGD
    Official Full Name
    brain enriched myelin associated protein 1provided by RGD
    Primary source
    RGD:628644
    See related
    Ensembl:ENSRNOG00000012906 AllianceGenome:RGD:628644
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Band83; Pmes-2
    Summary
    Predicted to be involved in myelination. Located in cytoplasm and postsynaptic density. Orthologous to human BCAS1 (brain enriched myelin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 495.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcas1 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (179554754..179637800, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (159136077..159219072, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (167957994..168033462, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486491 Neighboring gene uncharacterized LOC120101803 Neighboring gene ribosomal protein S23, pseudogene 5 Neighboring gene uncharacterized LOC120101805 Neighboring gene uncharacterized LOC134486493 Neighboring gene uncharacterized LOC134486494 Neighboring gene cytochrome P450, family 24, subfamily a, polypeptide 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel synaptosome-enriched mRNA that encodes 31 kDa protein. Ishimoto T, et al. Biochim Biophys Acta, 2002 Dec 12. PMID 12427555
    2. Mice lacking BCAS1, a novel myelin-associated protein, display hypomyelination, schizophrenia-like abnormal behaviors, and upregulation of inflammatory genes in the brain. Ishimoto T, et al. Glia, 2017 May. PMID 28230289
    3. Subcellular localization of PMES-2 proteins regulated by their two cytoskeleton-associated domains. Ninomiya K, et al. Cell Mol Neurobiol, 2005 Aug. PMID 16133941
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in myelination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in myelination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast carcinoma-amplified sequence 1 homolog
    Names
    band 83
    breast carcinoma amplified sequence 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415675.1 → NP_001402604.1  breast carcinoma-amplified sequence 1 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2K079, A0A8I6AQA4, A6JXS4
      Related
      ENSRNOP00000071338.2, ENSRNOT00000087579.2

    2. NM_145670.5 → NP_663703.3  breast carcinoma-amplified sequence 1 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      F1LN49, Q3ZB98, Q52KK0, Q5TLG8, Q5TLG9, Q5TLH0, Q5TLH1, Q8K4U9
      UniProtKB/TrEMBL
      A0A8I6AQA4
      Related
      ENSRNOP00000051984.2, ENSRNOT00000055111.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      179554754..179637800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283094.1 → XP_063139164.1  breast carcinoma-amplified sequence 1 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6A7B6

    2. XM_063283093.1 → XP_063139163.1  breast carcinoma-amplified sequence 1 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6AQA4

    3. XM_063283092.1 → XP_063139162.1  breast carcinoma-amplified sequence 1 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AQA4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ZB98.3 GenPept UniProtKB/Swiss-Prot:Q3ZB98

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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