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    Inf2 inverted formin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362790, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Inf2provided by RGD
    Official Full Name
    inverted formin 2provided by RGD
    Primary source
    RGD:1308350
    See related
    Ensembl:ENSRNOG00000028650 AllianceGenome:RGD:1308350
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308350
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within regulation of cellular component size and regulation of mitochondrial fission. Predicted to be located in perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease dominant intermediate E and focal segmental glomerulosclerosis 5. Orthologous to human INF2 (inverted formin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 61.1), Adrenal (RPKM 44.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Inf2 in Genome Data Viewer
    Location:
    6q32
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137470259..137497039)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131649162..131675944)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137162593..137180198)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 14 open reading frame 180 Neighboring gene transmembrane protein 179 Neighboring gene uncharacterized LOC102552388 Neighboring gene adenylosuccinate synthase 1 Neighboring gene SIVA1, apoptosis-inducing factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Brown EJ, et al. Nat Genet, 2010 Jan. PMID 20023659, Free PMC Article
    2. An actin-dependent step in mitochondrial fission mediated by the ER-associated formin INF2. Korobova F, et al. Science, 2013 Jan 25. PMID 23349293, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin nucleation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cellular component size ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inverted formin-2
    Names
    inverted formin, FH2 and WH2 domain containing

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427264.1 → NP_001414193.1  inverted formin-2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    2. NM_001427265.1 → NP_001414194.1  inverted formin-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      137470259..137497039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262154.1 → XP_063118224.1  inverted formin-2 isoform X5

      UniProtKB/TrEMBL
      E9PT22

    2. XM_039113407.2 → XP_038969335.1  inverted formin-2 isoform X6

      Conserved Domains (3) summary
      pfam06367
      Location:181 → 366
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:24 → 177
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:603 → 759
      FH2; Formin Homology 2 Domain

    3. XM_039113404.2 → XP_038969332.1  inverted formin-2 isoform X4

      Conserved Domains (5) summary
      PRK07764
      Location:1030 → 1217
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam06367
      Location:181 → 366
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:24 → 177
      Drf_GBD; Diaphanous GTPase-binding Domain
      cd22061
      Location:1013 → 1042
      WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
      cl19758
      Location:603 → 967
      FH2; Formin Homology 2 Domain

    4. XM_063262150.1 → XP_063118220.1  inverted formin-2 isoform X1

    5. XM_039113400.2 → XP_038969328.1  inverted formin-2 isoform X1

      Conserved Domains (5) summary
      PRK07764
      Location:1030 → 1217
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam06367
      Location:181 → 366
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:24 → 177
      Drf_GBD; Diaphanous GTPase-binding Domain
      cd22061
      Location:1013 → 1042
      WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
      cl19758
      Location:603 → 967
      FH2; Formin Homology 2 Domain

    6. XM_063262151.1 → XP_063118221.1  inverted formin-2 isoform X2

    7. XM_039113401.2 → XP_038969329.1  inverted formin-2 isoform X2

      Conserved Domains (5) summary
      PRK07764
      Location:1030 → 1217
      PRK07764; DNA polymerase III subunits gamma and tau; Validated
      pfam06367
      Location:181 → 366
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:24 → 177
      Drf_GBD; Diaphanous GTPase-binding Domain
      cd22061
      Location:1013 → 1042
      WH2_INF2; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Inverted formin-2 (INF2)
      cl19758
      Location:603 → 967
      FH2; Formin Homology 2 Domain

    8. XM_063262152.1 → XP_063118222.1  inverted formin-2 isoform X3

    9. XM_063262153.1 → XP_063118223.1  inverted formin-2 isoform X3

    RNA

    1. XR_005506360.2 RNA Sequence

    2. XR_005506355.2 RNA Sequence

    3. XR_005506354.2 RNA Sequence

    4. XR_005506356.2 RNA Sequence

    5. XR_005506358.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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