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    Noc2l NOC2 like nucleolar associated transcriptional repressor [ Mus musculus (house mouse) ]

    Gene ID: 57741, updated on 9-May-2024

    Summary

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    Official Symbol
    Noc2lprovided by MGI
    Official Full Name
    NOC2 like nucleolar associated transcriptional repressorprovided by MGI
    Primary source
    MGI:MGI:1931051
    See related
    Ensembl:ENSMUSG00000095567 AllianceGenome:MGI:1931051
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NIR
    Summary
    Predicted to enable several functions, including nucleosomal histone binding activity; p53 binding activity; and transcription corepressor activity. Predicted to be involved in several processes, including chromatin assembly; negative regulation of apoptotic process; and negative regulation of nitrogen compound metabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in chromosome; cytosol; and nucleus. Predicted to be part of Noc1p-Noc2p complex and Noc2p-Noc3p complex. Predicted to be active in nucleolus and nucleoplasm. Is expressed in several structures, including connective tissue; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human NOC2L (NOC2 like nucleolar associated transcriptional repressor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 56.2), thymus adult (RPKM 50.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Noc2l in Genome Data Viewer
    Location:
    4; 4 E2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (156319112..156332078)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (156234655..156247616)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing, family N member 1 Neighboring gene kelch-like 17 Neighboring gene microRNA 7658 Neighboring gene STARR-seq mESC enhancer starr_12292 Neighboring gene predicted gene, 52691 Neighboring gene sterile alpha motif domain containing 11 Neighboring gene predicted gene, 47252 Neighboring gene predicted gene, 54274

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel INHAT repressor (NIR) is required for early lymphocyte development. Ma CA, et al. Proc Natl Acad Sci U S A, 2014 Sep 23. PMID 25201955, Free PMC Article
    2. NIR is a novel INHAT repressor that modulates the transcriptional activity of p53. Hublitz P, et al. Genes Dev, 2005 Dec 1. PMID 16322561, Free PMC Article
    3. The histone acetyltransferase inhibitor Nir regulates epidermis development. Duteil D, et al. Development, 2018 Mar 21. PMID 29490983
    4. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Grebien F, et al. Nat Chem Biol, 2015 Aug. PMID 26167872, Free PMC Article
    5. Transcription factor Foxp3 and its protein partners form a complex regulatory network. Rudra D, et al. Nat Immunol, 2012 Oct. PMID 22922362, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data define Nir as a key regulator of skin development.
      Title: The histone acetyltransferase inhibitor Nir regulates epidermis development.
    2. results show that NIR cooperate with p53 to impose checkpoint for the generation of mature B and T lymphocytes.
      Title: Novel INHAT repressor (NIR) is required for early lymphocyte development.
    3. Upon recruitment by p53, NIR represses transcription of both p53-dependent reporters and endogenous target genes
      Title: NIR is a novel INHAT repressor that modulates the transcriptional activity of p53.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables p53 binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of B cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation-coupled chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Noc1p-Noc2p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Noc2p-Noc3p complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nucleolar complex protein 2 homolog
    Names
    NOC2-like protein
    novel INHAT repressor
    nucleolar complex associated 2 homolog
    protein NOC2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369270.2 → NP_001356199.1  nucleolar complex protein 2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      CAAA01066805, CAAA01066806
      UniProtKB/TrEMBL
      Q8BHX6
      Conserved Domains (1) summary
      pfam03715
      Location:174 → 469
      Noc2; Noc2p family

    2. NM_001424984.1 → NP_001411913.1  nucleolar complex protein 2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      CAAA01066805, CAAA01066806
      UniProtKB/TrEMBL
      Q8BHX6

    3. NM_001424985.1 → NP_001411914.1  nucleolar complex protein 2 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      CAAA01066805, CAAA01066806
      UniProtKB/TrEMBL
      Q8BHX6

    4. NM_001424986.1 → NP_001411915.1  nucleolar complex protein 2 homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      CAAA01066805, CAAA01066806

    5. NM_021303.3 → NP_067278.2  nucleolar complex protein 2 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      CAAA01066805, CAAA01066806
      Consensus CDS
      CCDS57322.1
      UniProtKB/Swiss-Prot
      Q8VE16, Q9WV70
      UniProtKB/TrEMBL
      J3QK52
      Related
      ENSMUSP00000137253.2, ENSMUST00000179543.8
      Conserved Domains (1) summary
      pfam03715
      Location:331 → 626
      Noc2; Noc2p family

    RNA

    1. NR_161236.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CAAA01066805, CAAA01066806

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      156319112..156332078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253688.1 → XP_030109548.1  nucleolar complex protein 2 homolog isoform X1

      UniProtKB/Swiss-Prot
      Q8VE16, Q9WV70
      Conserved Domains (1) summary
      pfam03715
      Location:358 → 653
      Noc2; Noc2p family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV70.2 GenPept UniProtKB/Swiss-Prot:Q9WV70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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