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    Ntmt1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362103, updated on 2-May-2024

    Summary

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    Official Symbol
    Ntmt1provided by RGD
    Official Full Name
    N-terminal Xaa-Pro-Lys N-methyltransferase 1provided by RGD
    Primary source
    RGD:1306582
    See related
    Ensembl:ENSRNOG00000024809 AllianceGenome:RGD:1306582
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    NTM1A; Mettl11a; RGD1306582
    Summary
    Predicted to enable N-terminal protein N-methyltransferase activity and histone methyltransferase activity. Predicted to be involved in chromosome segregation; protein methylation; and spindle organization. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NTMT1 (N-terminal Xaa-Pro-Lys N-methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 127.0), Muscle (RPKM 109.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ntmt1 in Genome Data Viewer
    Location:
    3p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (34490972..34508316)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (14093374..14110565)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (9642748..9659633)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554501 Neighboring gene similar to human chromosome 9 open reading frame 50 Neighboring gene ankyrin repeat and SOCS box-containing 6 Neighboring gene paired related homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for histone N-terminal methylation by NRMT1. Wu R, et al. Genes Dev, 2015 Nov 15. PMID 26543159, Free PMC Article
    2. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein. Tooley CE, et al. Nature, 2010 Aug 26. PMID 20668449, Free PMC Article
    3. Identification of protein N-terminal methyltransferases in yeast and humans. Webb KJ, et al. Biochemistry, 2010 Jun 29. PMID 20481588, Free PMC Article
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109213

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-terminal protein N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-terminal protein N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-terminal protein N-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables histone methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal peptidyl-alanine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-terminal peptidyl-proline methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in N-terminal peptidyl-serine methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in chromosome segregation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    N-terminal Xaa-Pro-Lys N-methyltransferase 1
    Names
    X-Pro-Lys N-terminal protein methyltransferase 1A
    alpha N-terminal protein methyltransferase 1A
    methyltransferase like 11A
    methyltransferase-like protein 11A
    NP_001020190.1
    XP_006233981.1
    XP_008759892.1
    XP_017447369.1
    XP_038961298.1
    XP_038961299.1
    XP_038961300.1
    XP_038961301.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025019.1 → NP_001020190.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1

      See identical proteins and their annotated locations for NP_001020190.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091294
      UniProtKB/Swiss-Prot
      Q5BJX0
      UniProtKB/TrEMBL
      A6JU01
      Related
      ENSRNOP00000035921.4, ENSRNOT00000035805.7
      Conserved Domains (1) summary
      pfam05891
      Location:8 → 223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      34490972..34508316
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233919.5 → XP_006233981.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZZE9
      Related
      ENSRNOP00000085096.1
      Conserved Domains (1) summary
      pfam05891
      Location:64 → 279
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase

    2. XM_039105372.2 → XP_038961300.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:64 → 166
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_039105371.2 → XP_038961299.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5BJX0
      UniProtKB/TrEMBL
      A6JU01
      Conserved Domains (1) summary
      pfam05891
      Location:8 → 223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase

    4. XM_039105370.2 → XP_038961298.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q5BJX0
      UniProtKB/TrEMBL
      A6JU01
      Conserved Domains (1) summary
      pfam05891
      Location:8 → 223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase

    5. XM_008761670.4 → XP_008759892.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X2

      See identical proteins and their annotated locations for XP_008759892.1

      UniProtKB/Swiss-Prot
      Q5BJX0
      UniProtKB/TrEMBL
      A6JU01
      Conserved Domains (1) summary
      pfam05891
      Location:8 → 223
      Methyltransf_PK; AdoMet dependent proline di-methyltransferase

    6. XM_017591880.3 → XP_017447369.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X4

      UniProtKB/TrEMBL
      A6JU03
      Conserved Domains (1) summary
      cl17173
      Location:1 → 135
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    7. XM_039105373.2 → XP_038961301.1  N-terminal Xaa-Pro-Lys N-methyltransferase 1 isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:26 → 193
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BJX0.3 GenPept UniProtKB/Swiss-Prot:Q5BJX0

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