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    Agfg2 ArfGAP with FG repeats 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304375, updated on 13-Apr-2024

    Summary

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    Symbol
    Agfg2provided by RGD
    Full Name
    ArfGAP with FG repeats 2provided by RGD
    Primary source
    RGD:1306590
    See related
    Ensembl:ENSRNOG00000001404 AllianceGenome:RGD:1306590
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hrbl
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of catalytic activity. Orthologous to human AGFG2 (ArfGAP with FG repeats 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 79.0), Spleen (RPKM 52.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agfg2 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (24649008..24692069)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19012228..19048433)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22082028..22118239)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1 Neighboring gene enoyl CoA hydratase domain containing 2, pseudogene 1 Neighboring gene insulin receptor substrate 3 Neighboring gene Sin3A-associated protein 25 Neighboring gene leucine rich repeats and calponin homology domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    arf-GAP domain and FG repeat-containing protein 2
    Names
    arf-GAP domain and FG repeat-containing protein 2-like
    arf-GAP domain and FG repeats-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107131.1 → NP_001100601.1  arf-GAP domain and FG repeat-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001100601.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473973
      UniProtKB/TrEMBL
      A0A8I6AU61, A6J006, D3ZNK4
      Related
      ENSRNOP00000060786.1, ENSRNOT00000064572.2

    2. NM_001400969.1 → NP_001387898.1  arf-GAP domain and FG repeat-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      Related
      ENSRNOP00000074192.2, ENSRNOT00000077711.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      24649008..24692069
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249142.5 → XP_006249204.1  arf-GAP domain and FG repeat-containing protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7G2
      Conserved Domains (1) summary
      cl02464
      Location:40 → 152
      ArfGap; Putative GTPase activating protein for Arf

    2. XM_063271280.1 → XP_063127350.1  arf-GAP domain and FG repeat-containing protein 2 isoform X3

    3. XM_006249141.5 → XP_006249203.1  arf-GAP domain and FG repeat-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZV55
      Related
      ENSRNOP00000082361.1
      Conserved Domains (1) summary
      cl02464
      Location:40 → 152
      ArfGap; Putative GTPase activating protein for Arf
    Nucleotide Protein Strain
    Heading Accession and Version

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