Ccnq cyclin Q [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccnqprovided by RGD
Official Full Name: cyclin Qprovided by RGD
Primary source: RGD:1305651
See related: Ensembl:ENSRNOG00000022582 AllianceGenome:RGD:1305651
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam58a; Fam58b; RGD1305651
Summary: Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity and protein kinase activator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of MAPK cascade. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to several human genes including CCNQ (cyclin Q). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 10q25

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (64144560..64145723, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (63646532..63647695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (66019519..66020682, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: cyclin-Q

Names: CDK10-activating cyclin; cyclin-M; cyclin-related protein FAM58A; family with sequence similarity 58, member B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025412.1 → NP_001020583.1 cyclin-Q

See identical proteins and their annotated locations for NP_001020583.1

Status: PROVISIONAL

Source sequence(s)

BC097941

UniProtKB/Swiss-Prot

Q4QQW5, Q5RJY7

UniProtKB/TrEMBL

A6HH70

Related

ENSRNOP00000011019.2, ENSRNOT00000011019.4

Conserved Domains (2) summary

cd20534
Location:29 → 137

CYCLIN_CCNM_CCNQ_rpt1; first cyclin box found in cyclin-M (CCNM) family

cd20535
Location:142 → 245

CYCLIN_CCNM_CCNQ_rpt2; second cyclin box found in cyclin-M (CCNM) family