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    ATPsyndelta ATP synthase, delta subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31950, updated on 10-May-2024

    Summary

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    Official Symbol
    ATPsyndeltaprovided by FlyBase
    Official Full Name
    ATP synthase, delta subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028342
    Locus tag
    Dmel_CG2968
    See related
    AllianceGenome:FB:FBgn0028342
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.109; anon-WO03040301.110; ATP5D; ATPD; CG2968; Dmel\CG2968; l (1) G0230; l(1)G0230
    Summary
    Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in ATP synthesis coupled proton transport. Located in mitochondrion. Is expressed in several structures, including adult heart; embryonic/larval midgut; extended germ band embryo; germ layer; and spermatozoon. Used to study inherited metabolic disorder. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency. Orthologous to human ATP5F1D (ATP synthase F1 subunit delta). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ATPsyndelta in Genome Data Viewer
    Location:
    9B4-9B4; 1-31 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (10212970..10217393)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (10107003..10111426)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44894 Neighboring gene long non-coding RNA:CR32690 Neighboring gene long non-coding RNA:CR43899 Neighboring gene antisense RNA:CR45629 Neighboring gene Yippee-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. Oláhová M, et al. Am J Hum Genet, 2018 Mar 1. PMID 29478781, Free PMC Article
    2. ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Teixeira FK, et al. Nat Cell Biol, 2015 May. PMID 25915123, Free PMC Article
    3. A Drosophila model for genetic analysis of influenza viral/host interactions. Adamson AL, et al. Genetics, 2011 Oct. PMID 21775472, Free PMC Article
    4. Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity. Rahman M, et al. J Cell Biol, 2014 Jul 21. PMID 25023514, Free PMC Article
    5. Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis. Bonnay F, et al. Cell, 2020 Sep 17. PMID 32916131

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase, central stalk ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ATP synthase, delta subunit
    Names
    ATP synthase delta chain
    ATPsyndelta-PA
    ATPsyndelta-PB
    ATPsyndelta-PC
    CG2968-PA
    CG2968-PB
    CG2968-PC
    F0/F1 ATP synthase delta
    lethal (1) G0230

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      10212970..10217393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298145.1 → NP_001285074.1  ATP synthase, delta subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285074.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2X6
      Conserved Domains (1) summary
      cd12152
      Location:27 → 141
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    2. NM_001272468.1 → NP_001259397.1  ATP synthase, delta subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259397.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2X6
      Conserved Domains (1) summary
      cd12152
      Location:27 → 141
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit

    3. NM_132382.3 → NP_572610.1  ATP synthase, delta subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W2X6
      Related
      FBpp0071373
      Conserved Domains (1) summary
      cd12152
      Location:27 → 141
      F1-ATPase_delta; mitochondrial ATP synthase delta subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2X6 Q9W2X6

    Gene LinkOut

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