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    Spase22-23 Spase 22/23-subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42885, updated on 10-May-2024

    Summary

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    Official Symbol
    Spase22-23provided by FlyBase
    Official Full Name
    Spase 22/23-subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039172
    Locus tag
    Dmel_CG5677
    See related
    AllianceGenome:FB:FBgn0039172
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5677; Dmel\CG5677; Spase22/23
    Summary
    Predicted to be involved in protein targeting to ER and signal peptide processing. Predicted to be integral component of membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including adult head; adult heart; egg chamber; and gut section. Orthologous to human SPCS3 (signal peptidase complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Spase22-23 in Genome Data Viewer
    Location:
    95F3-95F3; 3-84 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24228342..24230035, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20054064..20055757, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene twin Neighboring gene uncharacterized protein Neighboring gene caravaggio Neighboring gene long non-coding RNA:CR45217 Neighboring gene Sp1-like factor for pairing sensitive-silencing Neighboring gene long non-coding RNA:CR44092 Neighboring gene uncharacterized protein Neighboring gene Accessory gland protein 95EF Neighboring gene small Cajal body-specific RNA : MeU2-G25 Neighboring gene multiple ankyrin repeats single KH domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in protein targeting to ER IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of signal peptidase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of signal peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    spase 22/23-subunit
    Names
    CG5677-PA
    CG5677-PB
    Spase22-23-PA
    Spase22-23-PB
    Spase22/23-subunit

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24228342..24230035 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260350.2 → NP_001247279.1  spase 22/23-subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247279.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCA9
      UniProtKB/TrEMBL
      A0A0B4K7R1
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 172
      SPC22; Signal peptidase subunit

    2. NM_142977.5 → NP_651234.1  spase 22/23-subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651234.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VCA9
      UniProtKB/TrEMBL
      A0A0B4K7R1
      Related
      FBpp0083949
      Conserved Domains (1) summary
      pfam04573
      Location:4 → 172
      SPC22; Signal peptidase subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7R1 A0A0B4K7R1
    Q9VCA9.1 Q9VCA9

    Gene LinkOut

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    Other Literature Sources
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