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    SK small conductance calcium-activated potassium channel [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31456, updated on 10-May-2024

    Summary

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    Official Symbol
    SKprovided by FlyBase
    Official Full Name
    small conductance calcium-activated potassium channelprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029761
    Locus tag
    Dmel_CG10706
    See related
    AllianceGenome:FB:FBgn0029761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GM01744; CG10706; CG12733; CG4179; Dmel\CG10706; dSK; Sk
    Summary
    Enables photoreceptor activity and small conductance calcium-activated potassium channel activity. Involved in potassium ion transport and regulation of membrane potential in photoreceptor cell. Is integral component of membrane. Is expressed in several structures, including adult head; antennal lobe projection neurons; and sensory system neurons. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 2; paranoid schizophrenia; and schizophrenia. Orthologous to several human genes including KCNN1 (potassium calcium-activated channel subfamily N member 1) and KCNN2 (potassium calcium-activated channel subfamily N member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    4F5-4F9; 1-11 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5340236..5405138)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5234269..5299171)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene XRCC1 Neighboring gene Calcineurin B Neighboring gene Nutrient Amino Acid Transporter 1 Neighboring gene spoonbill

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the Drosophila SK channel (dSK) in courtship memory. Abou Tayoun AN, et al. PLoS One, 2012. PMID 22509342, Free PMC Article
    2. SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis. Castelli LM, et al. Mol Neurodegener, 2021 Aug 10. PMID 34376242, Free PMC Article
    3. Ca(2+)-Activated K(+) Channels Reduce Network Excitability, Improving Adaptability and Energetics for Transmitting and Perceiving Sensory Information. Li X, et al. J Neurosci, 2019 Sep 4. PMID 31350259, Free PMC Article
    4. Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ. Gertner DM, et al. J Neurophysiol, 2014 Jun 15. PMID 24671529, Free PMC Article
    5. Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera. Blow NS, et al. PLoS Pathog, 2005 Sep. PMID 16201020, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SK channel negatively regulates nociception.
      Title: The Drosophila Small Conductance Calcium-Activated Potassium Channel Negatively Regulates Nociception.
    2. Ca2+ entry at the postsynaptic membrane during spontaneous and evoked transmitter release activated the dSK channel to hyperpolarize the membrane and reduce EPSP amplitude
      Title: Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ.
    3. These findings highlight important functions for dSK in courtship memory and suggest that SK channels can mediate multiple forms of behavioral plasticity.
      Title: Roles of the Drosophila SK channel (dSK) in courtship memory.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables photoreceptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small conductance calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small conductance calcium-activated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables small conductance calcium-activated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of membrane potential in photoreceptor cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    small conductance calcium-activated potassium channel
    Names
    CG10706-PH
    CG10706-PI
    CG10706-PJ
    CG10706-PK
    CG10706-PL
    CG10706-PM
    CG10706-PN
    CG10706-PO
    CG10706-PP
    CG10706-PQ
    CG10706-PR
    CG10706-PS
    CG10706-PT
    CG10706-PU
    SK-PH
    SK-PI
    SK-PJ
    SK-PK
    SK-PL
    SK-PM
    SK-PN
    SK-PO
    SK-PP
    SK-PQ
    SK-PR
    SK-PS
    SK-PT
    SK-PU

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5340236..5405138
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206631.4 → NP_996354.2  small conductance calcium-activated potassium channel, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996354.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVW5
      Conserved Domains (3) summary
      pfam02888
      Location:763 → 835
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:475 → 583
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:670 → 749
      Ion_trans_2; Ion channel

    2. NM_001272324.2 → NP_001259253.1  small conductance calcium-activated potassium channel, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259253.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH41
      Conserved Domains (3) summary
      pfam02888
      Location:762 → 834
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:472 → 582
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:669 → 748
      Ion_trans_2; Ion channel

    3. NM_001272323.2 → NP_001259252.1  small conductance calcium-activated potassium channel, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259252.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG9
      Conserved Domains (3) summary
      pfam02888
      Location:762 → 834
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:472 → 582
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:669 → 748
      Ion_trans_2; Ion channel

    4. NM_001297958.1 → NP_001284887.1  small conductance calcium-activated potassium channel, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284887.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JDR8
      Conserved Domains (3) summary
      pfam02888
      Location:762 → 834
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:472 → 582
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:669 → 748
      Ion_trans_2; Ion channel

    5. NM_001272322.1 → NP_001259251.1  small conductance calcium-activated potassium channel, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259251.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDT6
      Conserved Domains (3) summary
      pfam02888
      Location:796 → 868
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:506 → 616
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:703 → 782
      Ion_trans_2; Ion channel

    6. NM_167029.3 → NP_726986.3  small conductance calcium-activated potassium channel, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726986.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Z5, A8WHR7, Q058W0, Q7KVW5, Q7KVW6, Q8IRR8, Q8IS28, Q8IS29, Q8MRM1, Q8MRR6, Q9W4C6, Q9W4C7
      Conserved Domains (3) summary
      pfam02888
      Location:763 → 835
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:475 → 583
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:670 → 749
      Ion_trans_2; Ion channel

    7. NM_001297960.1 → NP_001284889.1  small conductance calcium-activated potassium channel, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284889.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JAI8
      Conserved Domains (3) summary
      pfam02888
      Location:763 → 835
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:475 → 583
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:670 → 749
      Ion_trans_2; Ion channel

    8. NM_167031.3 → NP_726988.3  small conductance calcium-activated potassium channel, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726988.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVW5
      Conserved Domains (3) summary
      pfam02888
      Location:763 → 811
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:475 → 583
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:670 → 749
      Ion_trans_2; Ion channel

    9. NM_001103415.2 → NP_001096885.2  small conductance calcium-activated potassium channel, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096885.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A346DAQ0
      Conserved Domains (3) summary
      pfam02888
      Location:521 → 593
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:233 → 341
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:428 → 507
      Ion_trans_2; Ion channel

    10. NM_167032.2 → NP_726989.3  small conductance calcium-activated potassium channel, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726989.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVW5
      Conserved Domains (3) summary
      pfam02888
      Location:360 → 432
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:70 → 180
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:267 → 346
      Ion_trans_2; Ion channel

    11. NM_001297957.1 → NP_001284886.1  small conductance calcium-activated potassium channel, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284886.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JIE0
      Conserved Domains (3) summary
      pfam02888
      Location:360 → 432
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:70 → 180
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:267 → 346
      Ion_trans_2; Ion channel

    12. NM_080339.3 → NP_525078.3  small conductance calcium-activated potassium channel, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525078.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVW5
      Conserved Domains (3) summary
      pfam02888
      Location:358 → 430
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:70 → 178
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:265 → 344
      Ion_trans_2; Ion channel

    13. NM_001297959.1 → NP_001284888.1  small conductance calcium-activated potassium channel, isoform T [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284888.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JE69
      Conserved Domains (3) summary
      pfam02888
      Location:358 → 430
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:70 → 178
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:265 → 344
      Ion_trans_2; Ion channel

    14. NM_167030.2 → NP_726987.2  small conductance calcium-activated potassium channel, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726987.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KVW5
      Conserved Domains (3) summary
      pfam02888
      Location:358 → 430
      CaMBD; Calmodulin binding domain
      pfam03530
      Location:70 → 178
      SK_channel; Calcium-activated SK potassium channel
      pfam07885
      Location:265 → 344
      Ion_trans_2; Ion channel
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDT6 M9PDT6
    M9PGG9 M9PGG9
    M9PH41 M9PH41
    Q7KVW5.2 Q7KVW5
    Q8T3J7 Q8T3J7
    X2JAI8 X2JAI8
    X2JDR8 X2JDR8
    X2JE69 X2JE69
    X2JIE0 X2JIE0

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