Pbp2 phosphatidylethanolamine binding protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pbp2provided by MGI
Official Full Name: phosphatidylethanolamine binding protein 2provided by MGI
Primary source: MGI:MGI:1923650
See related: Ensembl:ENSMUSG00000047104 AllianceGenome:MGI:1923650
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pebp2; Pebp-2; 1700023A18Rik
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in negative regulation of MAPK cascade. Predicted to act upstream of or within negative regulation of peptidase activity. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human PEBP1 (phosphatidylethanolamine binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 6 G1; 6 66.17 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (135286127..135287382, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (135309129..135310384, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Therefore, we suggest that Chr 21 gene(s) distal from the ETS2 locus reduce mouse mlc2a and PEBP expression in DS model mice and DS.
Title: Human chromosome 21q22.2-qter carries a gene(s) responsible for downregulation of mlc2a and PEBP in Down syndrome model mice.
data show that phosphatidylethanolamine binding protein 2 (pebp-2) is a testis-specific 21-kDa protein found within late meiotic and haploid germ cells and colocalizes with members of the MAP kinase pathway in late spermatocytes and spermatids(pebp-2)
Title: Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2.

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General gene information

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Markers

NoName (e-PCR)
- UniSTS:489250

AI326308 (e-PCR)
- UniSTS:165494

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphatidylethanolamine-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029595.3 → NP_083871.3 phosphatidylethanolamine-binding protein 2

Status: VALIDATED

Source sequence(s)

AC122820

Consensus CDS

CCDS20646.1

UniProtKB/Swiss-Prot

Q3KND5, Q8VIN0, Q8VIN1, Q9DA20

UniProtKB/TrEMBL

E9QLE5

Related

ENSMUSP00000098414.2, ENSMUST00000050471.4

Conserved Domains (1) summary

cd00866
Location:23 → 171

PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes