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    Su(P) Suppressor of ref(2)P sterility [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39856, updated on 10-May-2024

    Summary

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    Official Symbol
    Su(P)provided by FlyBase
    Official Full Name
    Suppressor of ref(2)P sterilityprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004465
    Locus tag
    Dmel_CG4086
    See related
    AllianceGenome:FB:FBgn0004465
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4086; Dmel\CG4086
    Summary
    Predicted to enable prostaglandin-E synthase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including embryonic brain; embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; and mesoderm. Orthologous to human PTGES2 (prostaglandin E synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Su(P) in Genome Data Viewer
    Location:
    73B1-73B1; 3-44 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16610662..16612199, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16603762..16605299, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Artemis Neighboring gene uncharacterized protein Neighboring gene Proteasome beta6 subunit Neighboring gene antisense RNA:CR45865 Neighboring gene uncharacterized protein Neighboring gene Mo25

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of sigma virus multiplication by the ref(2)P gene of Drosophila melanogaster: an in vivo study of the PB1 domain of Ref(2)P. Carré-Mlouka A, et al. Genetics, 2007 May. PMID 17409092, Free PMC Article
    2. Long disordered regions of the C-terminal domain of Abelson tyrosine kinase have specific and additive functions in regulation and axon localization. Cheong HSJ, et al. PLoS One, 2017. PMID 29232713, Free PMC Article
    3. Genetic and molecular features of Su(P), a gene that interacts with ref(2)P in male fertility of Drosophila melanogaster. Bichon A, et al. Mol Genet Genomics, 2001 Apr. PMID 11361347
    4. A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster. Scarpati M, et al. PLoS One, 2019. PMID 30753230, Free PMC Article
    5. Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism. Grice SJ, et al. PLoS Genet, 2015 Mar. PMID 25816101, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables prostaglandin-E synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prostaglandin-E synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prostaglandin-E synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    suppressor of ref(2)P sterility
    Names
    CG4086-PA
    Su(P)-PA
    NP_524116.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      16610662..16612199 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079392.4 → NP_524116.2  suppressor of ref(2)P sterility [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524116.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U5V9, Q9V420
      Related
      FBpp0075118
      Conserved Domains (2) summary
      cd03197
      Location:247 → 400
      GST_C_mPGES2; C-terminal, alpha helical domain of microsomal Prostaglandin E synthase Type 2
      cd03040
      Location:124 → 201
      GST_N_mPGES2; GST_N family; microsomal Prostaglandin E synthase Type 2 (mPGES2) subfamily; mPGES2 is a membrane-anchored dimeric protein containing a CXXC motif which catalyzes the isomerization of PGH2 to PGE2. Unlike cytosolic PGE synthase (cPGES) and microsomal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O77287 O77287
    Q9U5V9 Q9U5V9
    Q9V420 Q9V420

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