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    Naaladl1 N-acetylated alpha-linked acidic dipeptidase-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 381204, updated on 2-May-2024

    Summary

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    Official Symbol
    Naaladl1provided by MGI
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase-like 1provided by MGI
    Primary source
    MGI:MGI:2685810
    See related
    Ensembl:ENSMUSG00000054999 AllianceGenome:MGI:2685810
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm964; Naaladasel
    Summary
    Predicted to enable exopeptidase activity; metal ion binding activity; and protein homodimerization activity. Predicted to be involved in peptide catabolic process. Predicted to be located in apical plasma membrane. Predicted to be integral component of membrane. Orthologous to human NAALADL1 (N-acetylated alpha-linked acidic dipeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in large intestine adult (RPKM 793.4), small intestine adult (RPKM 412.5) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Naaladl1 in Genome Data Viewer
    Location:
    19 A; 19 4.34 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6155811..6166019)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6105781..6115989)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3238 Neighboring gene STARR-positive B cell enhancer ABC_E4262 Neighboring gene cell division cycle associated 5 Neighboring gene predicted gene 550 Neighboring gene STARR-seq mESC enhancer starr_45420 Neighboring gene SAC3 domain containing 1 Neighboring gene sorting nexin 15 Neighboring gene STARR-positive B cell enhancer ABC_E11014

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
    2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase NAALADL1
    Names
    N-acetylated-alpha-linked acidic dipeptidase-like protein
    NAALADase L
    NP_001009546.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009546.2 → NP_001009546.1  aminopeptidase NAALADL1

      See identical proteins and their annotated locations for NP_001009546.1

      Status: VALIDATED

      Source sequence(s)
      AC131692
      Consensus CDS
      CCDS29494.1
      UniProtKB/Swiss-Prot
      Q7M758
      Related
      ENSMUSP00000044231.4, ENSMUST00000044451.4
      Conserved Domains (4) summary
      cd02121
      Location:114 → 344
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:350 → 592
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:642 → 739
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:53 → 126
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      6155811..6166019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7M758.1 GenPept UniProtKB/Swiss-Prot:Q7M758

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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