Cacna2d3 calcium channel, voltage-dependent, alpha2/delta subunit 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna2d3provided by MGI
Official Full Name: calcium channel, voltage-dependent, alpha2/delta subunit 3provided by MGI
Primary source: MGI:MGI:1338890
See related: Ensembl:ENSMUSG00000021991 AllianceGenome:MGI:1338890
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cacnad3; alapha2delta3
Summary: Predicted to enable voltage-gated calcium channel activity. Predicted to be involved in calcium ion transport. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of ion transmembrane transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and immune system. Orthologous to human CACNA2D3 (calcium voltage-gated channel auxiliary subunit alpha2delta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 15.3), CNS E18 (RPKM 9.9) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 16.8 cM

Exon count:: 39

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (28626900..29444732, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (28904943..29722775, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
Title: Deletions of Cacna2d3 in parvalbumin-expressing neurons leads to autistic-like phenotypes in mice.
Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice.
Title: Altered population activity and local tuning heterogeneity in auditory cortex of Cacna2d3-deficient mice.
Presynaptic alpha2delta subunits are key organizers of glutamatergic synapses.
Title: Presynaptic α(2)δ subunits are key organizers of glutamatergic synapses.
The data of this study demonstrate that knock out of CACN alpha2delta3 results in some structural abnormalities whose functional implications converge to dedifferentiation of sensory activation.
Title: Neuroanatomy of pain-deficiency and cross-modal activation in calcium channel subunit (CACN) α2δ3 knockout mice.
our results identify a novel role for the alpha2delta3 auxiliary subunit in the structure and function of specific synapses in the mammalian auditory pathway and in auditory processing disorders.
Title: α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders.
Mice mutant for the stj ortholog CACNA2D3 (alpha2delta3) exhibit impaired behavioral heat pain sensitivity.
Title: A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation
Transposon induced (1) 1 citation

General gene information

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Markers

D14Mit133 (e-PCR), detects polymorphism
- UniSTS:127239

D14Mit14 (e-PCR), detects polymorphism
- UniSTS:127246

31.MMHAP17FC4.seq (e-PCR)
- UniSTS:123930

A009K48 (e-PCR)
- UniSTS:81967

D14Mit173 (e-PCR), detects polymorphism
- UniSTS:127284

D14Mit173.1 (e-PCR), detects polymorphism
- UniSTS:127285

Cacna2d3 (e-PCR), detects polymorphism
- UniSTS:495938

D14Mit186 (e-PCR), detects polymorphism
- UniSTS:127299

AU022395 (e-PCR)
- UniSTS:209006

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of presynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IMP Inferred from Mutant Phenotype more info	PubMed
part_of voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-dependent calcium channel subunit alpha-2/delta-3

Names: alpha 2 delta-3; voltage-dependent calcium channel alpha2/delta-3 transcript; voltage-gated calcium channel subunit alpha-2/delta-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009785.1 → NP_033915.1 voltage-dependent calcium channel subunit alpha-2/delta-3 precursor

See identical proteins and their annotated locations for NP_033915.1

Status: PROVISIONAL

Source sequence(s)

AJ010949

UniProtKB/Swiss-Prot

Q9Z1L5

UniProtKB/TrEMBL

A0A411ACY3

Related

ENSMUSP00000022567.8, ENSMUST00000022567.9

Conserved Domains (4) summary

cd01463
Location:242 → 425

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:452 → 548

Cache_1; Cache domain

pfam08399
Location:113 → 229

VWA_N; VWA N-terminal

pfam08473
Location:561 → 633

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

28626900..29444732 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036158421.1 → XP_036014314.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X3

Conserved Domains (5) summary

cd01463
Location:242 → 395

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

cd12912
Location:472 → 586

PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains

cl38916
Location:416 → 470

HK_sensor; Sensor domains of Histidine Kinase receptors

pfam08399
Location:113 → 229

VWA_N; VWA N-terminal

pfam08473
Location:619 → 1032

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd
XM_011244938.4 → XP_011243240.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X2

Conserved Domains (5) summary

cd01463
Location:242 → 395

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

cd12912
Location:478 → 592

PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains

pfam08399
Location:113 → 229

VWA_N; VWA N-terminal

pfam08473
Location:625 → 1038

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:412 → 522

dCache_1; Cache domain
XM_006518486.5 → XP_006518549.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1

Conserved Domains (5) summary

cd01463
Location:242 → 425

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

cd12912
Location:502 → 616

PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains

pfam08399
Location:113 → 229

VWA_N; VWA N-terminal

pfam08473
Location:649 → 1062

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:442 → 546

dCache_1; Cache domain
XM_030247616.2 → XP_030103476.1 voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X4

Conserved Domains (5) summary

cd01463
Location:148 → 331

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

cd12912
Location:414 → 528

PDC2_MCP_like; second PDC (PhoQ/DcuS/CitA) domain of methyl-accepting chemotaxis proteins and similar domains

pfam08399
Location:19 → 135

VWA_N; VWA N-terminal

pfam08473
Location:561 → 974

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

pfam02743
Location:348 → 458

dCache_1; Cache domain