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    UTP10 snoRNA-binding rRNA-processing protein UTP10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853335, updated on 17-May-2024

    Summary

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    Gene symbol
    UTP10
    Gene description
    snoRNA-binding rRNA-processing protein UTP10
    Primary source
    FungiDB:YJL109C
    Locus tag
    YJL109C
    See related
    SGD:S000003645; AllianceGenome:SGD:S000003645; VEuPathDB:YJL109C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U3 snoRNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and positive regulation of transcription by RNA polymerase I. Located in nucleolus and rDNA heterochromatin. Part of several cellular components, including preribosome, small subunit precursor; small-subunit processome; and t-UTP complex. Human ortholog(s) of this gene implicated in pancreatic ductal carcinoma. Orthologous to human HEATR1 (HEAT repeat containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See UTP10 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (212000..217309, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene chaperonin-containing T-complex subunit CCT7 Neighboring gene Gzf3p Neighboring gene pheromone-regulated protein PRM10 Neighboring gene uncharacterized protein Neighboring gene protein kinase IME2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation. Dez C, et al. RNA, 2007 Sep. PMID 17652137, Free PMC Article
    2. A systematic study of gene expression variation at single-nucleotide resolution reveals widespread regulatory roles for uAUGs. Yun Y, et al. Genome Res, 2012 Jun. PMID 22454232, Free PMC Article
    3. Synergistic defects in pre-rRNA processing from mutations in the U3-specific protein Rrp9 and U3 snoRNA. Clerget G, et al. Nucleic Acids Res, 2020 Apr 17. PMID 31996908, Free PMC Article
    4. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Braun CM, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31745560, Free PMC Article
    5. The C-terminus of Utp4, mutated in childhood cirrhosis, is essential for ribosome biogenesis. Freed EF, et al. Nucleic Acids Res, 2010 Aug. PMID 20385600, Free PMC Article

    See all (90) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Required for pre-ribosomal RNA processing on the pathway of 18S synthesis.
      Title: Roles of the HEAT repeat proteins Utp10 and Utp20 in 40S ribosome maturation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase I IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, small subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of t-UTP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of t-UTP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snoRNA-binding rRNA-processing protein UTP10
    NP_012426.1
    • Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      212000..217309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181542.1 → NP_012426.1  TPA: snoRNA-binding rRNA-processing protein UTP10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012426.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW75, P42945
      UniProtKB/TrEMBL
      A0A8H4F9A5, B5VL65, C7GR07, C8ZBA7
      Conserved Domains (2) summary
      smart01036
      Location:1490 → 1637
      BP28CT; BP28CT (NUC211) domain
      pfam12397
      Location:231 → 355
      U3snoRNP10; U3 small nucleolar RNA-associated protein 10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6KE6_AE.1
    6LQP_AE.1
    6LQQ_AE.1
    6LQR_AE.1
    6LQS_AE.1
    6LQT_AE.1
    6LQU_AE.1
    6LQV_AE.1
    P42945.1

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