RPA43 DNA-directed RNA polymerase I subunit RPA43 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Gene symbol: RPA43
Gene description: DNA-directed RNA polymerase I subunit RPA43
Primary source: FungiDB:YOR340C
Locus tag: YOR340C
See related: SGD:S000005867; AllianceGenome:SGD:S000005867
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase I activity. Involved in nucleolar large rRNA transcription by RNA polymerase I. Part of RNA polymerase I complex. Orthologous to human POLR1F (RNA polymerase I subunit F). [provided by Alliance of Genome Resources, Apr 2022]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See RPA43 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (959202..960182, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Initiation-competent RNA polymerase I A43 subunit is associated with Rrn3, which stabilize A43.
Title: Structure of the initiation-competent RNA polymerase I and its implication for transcription.
Spt6 physically associates with a Pol I subunit (Rpa43).
Title: Spt6 Is Essential for rRNA Synthesis by RNA Polymerase I.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in DNA-templated transcription initiation	IEA Inferred from Electronic Annotation more info
involved_in nucleolar large rRNA transcription by RNA polymerase I	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase I	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription elongation by RNA polymerase I	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I complex	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: DNA-directed RNA polymerase I subunit RPA43

NP_014985.1

RNA polymerase I subunit A43

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

959202..960182 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183760.1 → NP_014985.1 TPA: DNA-directed RNA polymerase I subunit RPA43 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014985.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W335, P46669, Q99187

UniProtKB/TrEMBL

A0A8H4BVB1, A6ZPH0, B3LJZ9, B5VSL7, C7GNS6, C8ZH92, G2WNK2, N1NW87

Conserved Domains (2) summary

cd04328
Location:32 → 129

RNAP_I_Rpa43_N; Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an N-terminal RNP ...

pfam17875
Location:127 → 250

RPA43_OB; RPA43 OB domain in RNA Pol I

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
5LMX_G.1
5M3F_G.1
5M3M_G.1
5M5W_G.1
5N60_G.1
5N61_G.1
5OA1_G.1
5W5Y_G.1
5W64_G.1
5W65_G.1
5W66_G.1
6H67_G.1
6H68_G.1
6HKO_G.1
6HLQ_G.1
6HLR_G.1
6HLS_G.1
P46669.2