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    NOP58 RNA-processing protein NOP58 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854487, updated on 17-May-2024

    Summary

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    Gene symbol
    NOP58
    Gene description
    RNA-processing protein NOP58
    Primary source
    FungiDB:YOR310C
    Locus tag
    YOR310C
    See related
    SGD:S000005837; AllianceGenome:SGD:S000005837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NOP5
    Summary
    Enables mRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of box C/D RNP complex and small-subunit processome. Orthologous to human NOP58 (NOP58 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See NOP58 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (896825..898360, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Sly41p Neighboring gene U4/U6-U5 snRNP complex subunit SNU66 Neighboring gene diacylglycerol kinase Neighboring gene ribosomal 60S subunit protein L20B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. Wu P, et al. J Biol Chem, 1998 Jun 26. PMID 9632712, Free PMC Article
    2. Assembly into snoRNP controls 5'-end maturation of a box C/D snoRNA in Saccharomyces cerevisiae. Preti M, et al. Biochem Biophys Res Commun, 2006 Dec 15. PMID 17064667
    3. High-resolution structure of eukaryotic Fibrillarin interacting with Nop56 amino-terminal domain. Höfler S, et al. RNA, 2021 Apr. PMID 33483369, Free PMC Article
    4. Structure/Function Analysis of Protein-Protein Interactions Developed by the Yeast Pih1 Platform Protein and Its Partners in Box C/D snoRNP Assembly. Quinternet M, et al. J Mol Biol, 2015 Aug 28. PMID 26210662
    5. Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro. Galardi S, et al. Mol Cell Biol, 2002 Oct. PMID 12215523, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yeast R2TP Interacts with Extended Termini of Client Protein Nop58p.
      Title: Yeast R2TP Interacts with Extended Termini of Client Protein Nop58p.
    2. Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.
      Title: Bcd1p controls RNA loading of the core protein Nop58 during C/D box snoRNP biogenesis.
    3. Results show that Nop58 strongly interacts with the R2TP complex through its interaction with Pih1 resulting in Nop58 stabilization.
      Title: Nutritional status modulates box C/D snoRNP biogenesis by regulated subcellular relocalization of the R2TP complex.
    4. Nop17p depletion leads to mislocalization of Nop1p, Nop56p, Nop58p and Snu13p, which are the core proteins of the box C/D ribonucleoprotein
      Title: Characterization of Saccharomyces cerevisiae Nop17p, a novel Nop58p-interacting protein that is involved in Pre-rRNA processing.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of box C/D methylation guide snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of box C/D methylation guide snoRNP complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of box C/D methylation guide snoRNP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of small-subunit processome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-processing protein NOP58
    NP_014955.1
    • Protein involved in producing mature rRNAs and snoRNAs; involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      896825..898360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183730.1 → NP_014955.1  TPA: RNA-processing protein NOP58 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014955.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZPE5, D6W309, Q12499
      UniProtKB/TrEMBL
      A0A8H4FAH9, B3LJX4, C7GNV1, G2WNH6, N1NXG4
      Conserved Domains (2) summary
      COG1498
      Location:42 → 436
      SIK1; RNA processing factor Prp31, contains Nop domain [Translation, ribosomal structure and biogenesis]
      pfam08156
      Location:3 → 66
      NOP5NT; NOP5NT (NUC127) domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6KE6_3E.1
    6LQP_3E.1
    6LQQ_3E.1
    6LQR_3E.1
    6LQS_3E.1
    6LQT_3E.1
    6LQU_3E.1
    6LQV_3E.1
    Q12499.1

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