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    Bpnt1 3'(2'), 5'-bisphosphate nucleotidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 23827, updated on 12-May-2024

    Summary

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    Official Symbol
    Bpnt1provided by MGI
    Official Full Name
    3'(2'), 5'-bisphosphate nucleotidase 1provided by MGI
    Primary source
    MGI:MGI:1338800
    See related
    Ensembl:ENSMUSG00000026617 AllianceGenome:MGI:1338800
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BPntase
    Summary
    Enables 3'(2'),5'-bisphosphate nucleotidase activity. Predicted to be involved in inositol phosphate dephosphorylation and phosphatidylinositol phosphate biosynthetic process. Is expressed in apical ectodermal ridge and limb. Orthologous to human BPNT1 (3'(2'), 5'-bisphosphate nucleotidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 27.7), kidney adult (RPKM 26.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bpnt1 in Genome Data Viewer
    Location:
    1 H5; 1 89.49 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (185061619..185089974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (185329428..185357777)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene isoleucine-tRNA synthetase 2, mitochondrial Neighboring gene RIKEN cDNA 2010103J01 gene Neighboring gene microRNA 194-1 Neighboring gene microRNA 215 Neighboring gene STARR-seq mESC enhancer starr_03326 Neighboring gene STARR-seq mESC enhancer starr_03328 Neighboring gene STARR-positive B cell enhancer ABC_E4403 Neighboring gene STARR-positive B cell enhancer ABC_E3350 Neighboring gene glutamyl-prolyl-tRNA synthetase 1 Neighboring gene RIKEN cDNA 9630028B13 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Modulation of intestinal sulfur assimilation metabolism regulates iron homeostasis. Hudson BH, et al. Proc Natl Acad Sci U S A, 2018 Mar 20. PMID 29507250, Free PMC Article
    2. Tissue-specific regulation of 3'-nucleotide hydrolysis and nucleolar architecture. Hudson BH, et al. Adv Biol Regul, 2014 Jan. PMID 24309248, Free PMC Article
    3. Modulation of sulfur assimilation metabolic toxicity overcomes anemia and hemochromatosis in mice. Hale AT, et al. Adv Biol Regul, 2020 May. PMID 32019729, Free PMC Article
    4. Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis. Hudson BH, et al. Proc Natl Acad Sci U S A, 2013 Mar 26. PMID 23479625, Free PMC Article
    5. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. Spiegelberg BD, et al. J Biol Chem, 1999 May 7. PMID 10224133

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'(2'),5'-bisphosphate nucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'(2'),5'-bisphosphate nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3'(2'),5'-bisphosphate nucleotidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-1,4-bisphosphate 1-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    3'(2'),5'-bisphosphate nucleotidase 1
    Names
    3'-phosphoadenosine 5'-phosphate phosphatase
    BPntase 1
    PAP phosphatase
    PAP-inositol 1,4-phosphatase
    PIP
    bisphosphate 3'-nucleotidase 1
    inositol-polyphosphate 1-phosphatase
    NP_001334139.1
    NP_001334141.1
    NP_035924.2
    XP_006497223.1
    XP_006497224.1
    XP_030109781.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347210.1 → NP_001334139.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC129195
      Consensus CDS
      CCDS83657.1
      UniProtKB/TrEMBL
      A0A1B0GRV0, Q3UBN8
      Related
      ENSMUSP00000147674.2, ENSMUST00000210277.2
      Conserved Domains (1) summary
      cd01640
      Location:11 → 311
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    2. NM_001347212.1 → NP_001334141.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC129195
      Consensus CDS
      CCDS83658.1
      UniProtKB/TrEMBL
      D3Z0E6, Q3UBN8
      Related
      ENSMUSP00000106590.2, ENSMUST00000110965.2

    3. NM_011794.3 → NP_035924.2  3'(2'),5'-bisphosphate nucleotidase 1 isoform 1

      See identical proteins and their annotated locations for NP_035924.2

      Status: VALIDATED

      Source sequence(s)
      AC129195
      Consensus CDS
      CCDS15597.1
      UniProtKB/Swiss-Prot
      Q3U8Z5, Q91XB9, Q9D7Y0, Q9Z0S1
      UniProtKB/TrEMBL
      Q3UBN8
      Related
      ENSMUSP00000027916.7, ENSMUST00000027916.13
      Conserved Domains (1) summary
      cd01640
      Location:11 → 296
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      185061619..185089974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497160.5 → XP_006497223.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X1

      See identical proteins and their annotated locations for XP_006497223.1

      UniProtKB/TrEMBL
      A0A1B0GRV0, Q3UBN8
      Conserved Domains (1) summary
      cd01640
      Location:11 → 311
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    2. XM_030253921.2 → XP_030109781.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X2

      UniProtKB/Swiss-Prot
      Q3U8Z5, Q91XB9, Q9D7Y0, Q9Z0S1
      UniProtKB/TrEMBL
      Q3UBN8
      Conserved Domains (1) summary
      cd01640
      Location:11 → 296
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...

    3. XM_006497161.5 → XP_006497224.1  3'(2'),5'-bisphosphate nucleotidase 1 isoform X3

      UniProtKB/TrEMBL
      Q3UBN8
      Conserved Domains (1) summary
      cd01640
      Location:1 → 256
      IPPase; Inositol polyphosphate-1-phosphatase, a member of the Mg++ dependent family of inositol monophosphatase-like domains, hydrolyzes the 1' position phosphate from inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. Members in this group may also ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z0S1.2 GenPept UniProtKB/Swiss-Prot:Q9Z0S1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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