Parl presenilin associated, rhomboid-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parlprovided by RGD
Official Full Name: presenilin associated, rhomboid-likeprovided by RGD
Primary source: RGD:1306191
See related: Ensembl:ENSRNOG00000023271 AllianceGenome:RGD:1306191
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Psarl
Summary: Predicted to enable serine-type endopeptidase activity. Involved in neuron differentiation and response to nutrient levels. Located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; coronary artery disease; hyperinsulinism; myopia; and type 2 diabetes mellitus. Orthologous to human PARL (presenilin associated rhomboid like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 205.4), Thymus (RPKM 183.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q23

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (94097559..94124915)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (80594059..80620506)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (84517368..84544463)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High-fat-diet-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle, and may be the result of the decreased expression of the PARL gene.
Title: Variation in gene expression of presenilins-associated rhomboid-like protein and mitochondrial function in skeletal muscle of insulin-resistant rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in membrane protein proteolysis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in protein processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to nutrient levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: presenilin-associated rhomboid-like protein, mitochondrial

Names: mitochondrial intramembrane-cleaving protease PARL; presenilins-associated rhomboid-like protein, mitochondrial

NP_001030326.1

EC 3.4.21.105

XP_038944015.2

EC 3.4.21.105

XP_038944016.2

EC 3.4.21.105

XP_038944017.2

EC 3.4.21.105

XP_063126398.1

EC 3.4.21.105

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001035249.1 → NP_001030326.1 presenilin-associated rhomboid-like protein, mitochondrial precursor

See identical proteins and their annotated locations for NP_001030326.1

Status: PROVISIONAL

Source sequence(s)

BC105907

UniProtKB/Swiss-Prot

Q3B8P0, Q5I0L2

UniProtKB/TrEMBL

B0BMU4, F1LPN4

Related

ENSRNOP00000029124.7, ENSRNOT00000030837.8

Conserved Domains (1) summary

pfam01694
Location:207 → 348

Rhomboid; Rhomboid family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

94097559..94124915

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088087.2 → XP_038944015.2 presenilin-associated rhomboid-like protein, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8I6GKF1
XM_039088088.2 → XP_038944016.2 presenilin-associated rhomboid-like protein, mitochondrial isoform X2
XM_039088089.2 → XP_038944017.2 presenilin-associated rhomboid-like protein, mitochondrial isoform X3

UniProtKB/TrEMBL

A0A8I6GKF1
XM_063270328.1 → XP_063126398.1 presenilin-associated rhomboid-like protein, mitochondrial isoform X4