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    Hipk3 homeodomain interacting protein kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83617, updated on 2-May-2024

    Summary

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    Official Symbol
    Hipk3provided by RGD
    Official Full Name
    homeodomain interacting protein kinase 3provided by RGD
    Primary source
    RGD:619884
    See related
    Ensembl:ENSRNOG00000011358 AllianceGenome:RGD:619884
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    ANPK
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in several processes, including mRNA transcription; negative regulation of JUN kinase activity; and protein phosphorylation. Predicted to be located in cytosol; nuclear body; and plasma membrane. Predicted to be active in PML body and cytoplasm. Orthologous to human HIPK3 (homeodomain interacting protein kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 646.6), Muscle (RPKM 605.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hipk3 in Genome Data Viewer
    Location:
    3q32
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (111251863..111322815, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (90796980..90866701, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (94349778..94419185, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA D430041D05 gene like Neighboring gene similar to human chromosome 11 open reading frame 91 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene cleavage stimulation factor subunit 3 Neighboring gene t-complex 11 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway. Liu B, et al. Inflammation, 2020 Jun. PMID 32356246
    2. Overexpression of miR-431 inhibits cardiomyocyte apoptosis following myocardial infarction via targeting HIPK3. Ma ZF, et al. Eur Rev Med Pharmacol Sci, 2021 Feb. PMID 33660818
    3. Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. Lan HC, et al. Mol Cell Biol, 2007 Mar. PMID 17210646, Free PMC Article
    4. JNK regulates HIPK3 expression and promotes resistance to Fas-mediated apoptosis in DU 145 prostate carcinoma cells. Curtin JF, et al. J Biol Chem, 2004 Apr 23. PMID 14766760
    5. Estrogenic induction of spermatogenesis in the hypogonadal mouse. Ebling FJ, et al. Endocrinology, 2000 Aug. PMID 10919273

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.
      Title: MiR-21 attenuates FAS-mediated cardiomyocyte apoptosis by regulating HIPK3 expression.
    2. Overexpression of miR-431 inhibits cardiomyocyte apoptosis following myocardial infarction via targeting HIPK3.
      Title: Overexpression of miR-431 inhibits cardiomyocyte apoptosis following myocardial infarction via targeting HIPK3.
    3. HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway.
      Title: HIPK3 Mediates Inflammatory Cytokines and Oxidative Stress Markers in Monocytes in a Rat Model of Sepsis Through the JNK/c-Jun Signaling Pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in PML body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    homeodomain-interacting protein kinase 3
    Names
    androgen receptor-interacting nuclear protein kinase
    nuclear serine/threonine protein kinase
    NP_001382009.1
    NP_113975.2
    XP_008760294.2
    XP_063140716.1
    XP_063140717.1
    XP_063140718.1
    XP_063140719.1
    XP_063140720.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395080.1 → NP_001382009.1  homeodomain-interacting protein kinase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88850
      UniProtKB/TrEMBL
      Q498U5
      Related
      ENSRNOP00000085704.1, ENSRNOT00000105868.1
      Conserved Domains (1) summary
      cd14229
      Location:196 → 525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    2. NM_031787.2 → NP_113975.2  homeodomain-interacting protein kinase 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      O88850
      UniProtKB/TrEMBL
      A6HNU0, F7EY07
      Related
      ENSRNOP00000015775.2, ENSRNOT00000015775.4
      Conserved Domains (1) summary
      cd14229
      Location:196 → 525
      STKc_HIPK3; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      111251863..111322815 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008762072.4 → XP_008760294.2  homeodomain-interacting protein kinase 3 isoform X6

    2. XM_063284647.1 → XP_063140717.1  homeodomain-interacting protein kinase 3 isoform X2

    3. XM_063284646.1 → XP_063140716.1  homeodomain-interacting protein kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6GE65

    4. XM_063284650.1 → XP_063140720.1  homeodomain-interacting protein kinase 3 isoform X5

    5. XM_063284649.1 → XP_063140719.1  homeodomain-interacting protein kinase 3 isoform X4

    6. XM_063284648.1 → XP_063140718.1  homeodomain-interacting protein kinase 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88850.1 GenPept UniProtKB/Swiss-Prot:O88850

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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