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    Cgrrf1 cell growth regulator with ring finger domain 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116679, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Cgrrf1provided by RGD
    Official Full Name
    cell growth regulator with ring finger domain 1provided by RGD
    Primary source
    RGD:620803
    See related
    Ensembl:ENSRNOG00000010178 AllianceGenome:RGD:620803
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cgr19
    Summary
    Predicted to enable metal ion binding activity. Involved in negative regulation of cell growth. Predicted to be located in endoplasmic reticulum and nucleoplasm. Orthologous to human CGRRF1 (cell growth regulator with ring finger domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 226.0), Liver (RPKM 149.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cgrrf1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (22560902..22588815)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (20088564..20109042)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (23619176..23639622)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene cornichon family member 1 Neighboring gene glia maturation factor, beta Neighboring gene ribosomal protein L39, pseudogene 11 Neighboring gene uncharacterized LOC102548367 Neighboring gene sterile alpha motif domain containing 4A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Induction of cell growth regulatory genes by p53. Madden SL, et al. Cancer Res, 1996 Dec 1. PMID 8968090
    2. Genome-wide identification and gene expression profiling of ubiquitin ligases for endoplasmic reticulum protein degradation. Kaneko M, et al. Sci Rep, 2016 Aug 3. PMID 27485036, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93274

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cell growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell growth regulator with RING finger domain protein 1
    Names
    cell growth regulatory gene 19 protein
    cell growth regulatory with ring finger domain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053899.2 → NP_446351.2  cell growth regulator with RING finger domain protein 1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      P97587
      UniProtKB/TrEMBL
      A6KE27, G3V7C9
      Related
      ENSRNOP00000013912.3, ENSRNOT00000013912.7
      Conserved Domains (1) summary
      cd16787
      Location:273 → 309
      mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      22560902..22588815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273912.1 → XP_063129982.1  cell growth regulator with RING finger domain protein 1 isoform X2

      UniProtKB/Swiss-Prot
      P97587
      UniProtKB/TrEMBL
      A6KE27, G3V7C9

    2. XM_039092952.1 → XP_038948880.1  cell growth regulator with RING finger domain protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P97587
      Conserved Domains (1) summary
      cd16787
      Location:298 → 334
      mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

    3. XM_039092954.2 → XP_038948882.1  cell growth regulator with RING finger domain protein 1 isoform X4

      UniProtKB/TrEMBL
      A6KE30
      Conserved Domains (1) summary
      cd16787
      Location:204 → 240
      mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins

    4. XM_039092953.2 → XP_038948881.1  cell growth regulator with RING finger domain protein 1 isoform X3

      Conserved Domains (1) summary
      cd16787
      Location:229 → 265
      mRING-HC-C3HC5_CGRF1; Modified RING finger, HC subclass (C3HC5-type), found in cell growth regulator with RING finger domain protein 1 (CGRRF1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97587.1 GenPept UniProtKB/Swiss-Prot:P97587

    Gene LinkOut

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