Gucy2c guanylate cyclase 2c [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gucy2cprovided by MGI
Official Full Name: guanylate cyclase 2cprovided by MGI
Primary source: MGI:MGI:106903
See related: Ensembl:ENSMUSG00000042638 AllianceGenome:MGI:106903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gcc; GC-C
Summary: Enables guanylate cyclase activity. Acts upstream of or within regulation of cell population proliferation and response to toxic substance. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in alimentary system and liver. Used to study abdominal obesity-metabolic syndrome and obesity. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 40.4), colon adult (RPKM 29.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 66.67 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (136674282..136758740, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (136697284..136781742, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Intestinal neuropod cell GUCY2C regulates visceral pain.
Title: Intestinal neuropod cell GUCY2C regulates visceral pain.
Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
Title: Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C.
The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model.
Title: The endogenous ligand for guanylate cyclase-C activation reliefs intestinal inflammation in the DSS colitis model.
Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.
Title: Activation of brown adipose tissue in diet-induced thermogenesis is GC-C dependent.
Study reveals two discrete neuronal circuits expressing GUCY2C originating in the ventral premammillary nucleus in the hypothalamus and in the ventral tegmental area and substantia nigra in midbrain, which separately project to other sites throughout the brain.
Title: Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.
Gucy2c knockout mice have a moderate cognitive and startle phenotype but have no ADHD-like phenotype.
Title: Mouse knockout of guanylyl cyclase C: Recognition memory deficits in the absence of activity changes.
This retrogenic model can be employed to define self-tolerance mechanisms restricting T and B cell responses to GUCY2C to optimize colorectal cancer immunotherapy without autoimmunity.
Title: TCR Retrogenic Mice as a Model To Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen GUCY2C.
Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.
Title: Activation of guanylate cyclase-C attenuates stretch responses and sensitization of mouse colorectal afferents.
Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival.
Title: Guanylate cyclase C reduces invasion of intestinal epithelial cells by bacterial pathogens.
Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome.
Title: GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI893437 (e-PCR)
- UniSTS:179481

Gucy2c (e-PCR), detects polymorphism
- UniSTS:516668

Gucy2c (e-PCR), detects polymorphism
- UniSTS:525452

Gucy2c (e-PCR), detects polymorphism
- UniSTS:546810

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanylate cyclase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables guanylate cyclase activity	ISO Inferred from Sequence Orthology more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables peptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphorus-oxygen lyase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables toxic substance binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cyclic nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to toxic substance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: guanylyl cyclase C

Names: STA receptor; heat-stable enterotoxin receptor; intestinal guanylate cyclase

NP_001120790.1

EC 4.6.1.2

NP_659504.2

EC 4.6.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127318.1 → NP_001120790.1 guanylyl cyclase C isoform 1 precursor

See identical proteins and their annotated locations for NP_001120790.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and and encodes the longer isoform (1).

Source sequence(s)

AK136496, CF353627

Consensus CDS

CCDS51941.1

UniProtKB/Swiss-Prot

Q3UWA6, Q499D2, Q8JZQ6

Related

ENSMUSP00000032338.8, ENSMUST00000032338.10

Conserved Domains (5) summary

smart00044
Location:787 → 978

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

smart00221
Location:502 → 744

STYKc; Protein kinase; unclassified specificity

pfam00211
Location:814 → 1001

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

cl10011
Location:35 → 415

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:480 → 749

PKc_like; Protein Kinases, catalytic domain
NM_145067.3 → NP_659504.2 guanylyl cyclase C isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AK136496, CF353627

Consensus CDS

CCDS20653.1

UniProtKB/Swiss-Prot

Q3UWA6

Related

ENSMUSP00000077236.7, ENSMUST00000078095.11

Conserved Domains (4) summary

smart00044
Location:763 → 954

CYCc; Adenylyl- / guanylyl cyclase, catalytic domain

pfam00211
Location:790 → 977

Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain

cl10011
Location:35 → 415

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

cl21453
Location:480 → 725

PKc_like; Protein Kinases, catalytic domain