Atoh8 atonal bHLH transcription factor 8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atoh8provided by MGI
Official Full Name: atonal bHLH transcription factor 8provided by MGI
Primary source: MGI:MGI:1918343
See related: Ensembl:ENSMUSG00000037621 AllianceGenome:MGI:1918343
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hath6; Math6; okadin; bHLHa21; 4933425C05Rik
Summary: Enables DNA-binding transcription factor activity and DNA-binding transcription factor binding activity. Involved in formation of primary germ layer; myoblast proliferation; and negative regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in several structures, including aorta; central nervous system; genitourinary system; heart; and lung. Orthologous to human ATOH8 (atonal bHLH transcription factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 68.7), lung adult (RPKM 9.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 C1; 6 32.27 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (72183158..72212765, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (72206174..72235780, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeted deletion of Atoh8 results in severe hearing loss in mice.
Title: Targeted deletion of Atoh8 results in severe hearing loss in mice.
The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
Title: The ALK-1/SMAD/ATOH8 axis attenuates hypoxic responses and protects against the development of pulmonary arterial hypertension.
These data suggested that GDF5 regulates neuron differentiation through mediating Atoh8
Title: Growth/differentiation 5 promotes the differentiation of retinal stem cells into neurons via Atoh8.
Atoh8 regulates chondrocyte proliferation in parallel or downstream of Ihh signaling while it acts on the onset of hypertrophy upstream of Ihh likely by modulating Ihh expression levels
Title: Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones.
Math6 counteracts TGF beta signaling.
Title: bHLH Transcription Factor Math6 Antagonizes TGF-β Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions.
To analyze the in vivo function of Math6 in detail, we generated a constitutive knockout (KO) mouse (Math6(-/-)) and performed an initial histological and molecular biological investigation of its main phenotype. Pregnant Math6(-/-) females suffer from a disturbed early placental development leading to the death of the majority of embryos independent of the embryonic Math6 genotype
Title: Murine transcription factor Math6 is a regulator of placenta development.
ATOH8 is an important transcriptional regulator of hepcidin in beta-thalassemia.
Title: Hepcidin suppression in β-thalassemia is associated with the down-regulation of atonal homolog 8.
Atoh8 modulates activation of the endocrine program.
Title: Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).
It has observed Math6 expression in various organs at early and late stages of mouse development, which illustrates the involvement of Math6 in multiple developmental events.
Title: Spatiotemporal expression of Math6 during mouse embryonic development.
results reveal distinctive transcriptional properties of Atoh8 within the atonal-related bHLH family that may be associated with the acquisition of new biological functions.
Title: Characterization of the transcriptional activity of the basic helix-loop-helix (bHLH) transcription factor Atoh8.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:548446

Atoh8 (e-PCR), detects polymorphism
- UniSTS:545899

PMC196074P2 (e-PCR)
- UniSTS:271797

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in formation of primary germ layer	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in myoblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tube formation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor Atoh8

Names: atonal homolog 8; basic helix-loop-helix transcription factor 6; helix-loop-helix protein mATH-6; protein atonal homolog 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.