Trim6 tripartite motif-containing 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim6provided by MGI
Official Full Name: tripartite motif-containing 6provided by MGI
Primary source: MGI:MGI:2137352
See related: Ensembl:ENSMUSG00000072244 AllianceGenome:MGI:2137352
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D7Ertd684e; C430046K18Rik
Summary: Enables DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Located in cytosol and nucleus. Is expressed in testis. Orthologous to human TRIM6 (tripartite motif containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in placenta adult (RPKM 14.8) and colon adult (RPKM 1.4) See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 55.55 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (103868002..103884359)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (104218795..104235152)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.
Title: TRIM6 silencing for inhibiting growth and angiogenesis of gliomas by regulating VEGFA.
TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.
Title: TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer.
these results suggest that TRIM6 aggravates MI/R injury through promoting IKKepsilon/STAT1 activation-dependent cardiomyocyte apoptosis
Title: E3-ubiquitin ligase TRIM6 aggravates myocardial ischemia/reperfusion injury via promoting STAT1-dependent cardiomyocyte apoptosis.
TRIM6 regulates the transcriptional activity of Myc during the maintenance of cell pluripotency, suggesting that TRIM6 functions as a novel regulator for Myc-mediated transcription in embryonic stem cells.
Title: TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

AW536332 (e-PCR)
- UniSTS:208170

D11Bhm20 (e-PCR), detects polymorphism
- UniSTS:141619

D9Mit34.1 (e-PCR), detects polymorphism
- UniSTS:131903

D7Ertd684e (e-PCR), detects polymorphism
- UniSTS:167539

NoName (e-PCR)
- UniSTS:235735

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in free ubiquitin chain polymerization	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription regulatory region DNA binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein localization	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of viral entry into host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: tripartite motif-containing protein 6

Names: RING-type E3 ubiquitin transferase TRIM6; tripartite motif protein 6

NP_001013637.1

EC 2.3.2.27

XP_006508427.1

EC 2.3.2.27

XP_006508428.1

EC 2.3.2.27

XP_006508429.1

EC 2.3.2.27

XP_017167896.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013616.2 → NP_001013637.1 tripartite motif-containing protein 6

See identical proteins and their annotated locations for NP_001013637.1

Status: VALIDATED

Source sequence(s)

AC123830, AK049238, BB634731

Consensus CDS

CCDS40065.1

UniProtKB/Swiss-Prot

B2RSQ8, Q8BGE7, Q99PQ6

UniProtKB/TrEMBL

A0A1L1SS93

Related

ENSMUSP00000095782.4, ENSMUST00000098180.10

Conserved Domains (4) summary

TIGR03319
Location:145 → 238

RNase_Y; ribonuclease Y

cd15823
Location:299 → 486

SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)

cd16591
Location:12 → 61

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cd19761
Location:97 → 134

Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

103868002..103884359

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312407.2 → XP_017167896.1 tripartite motif-containing protein 6 isoform X2

Conserved Domains (3) summary

TIGR03319
Location:145 → 238

RNase_Y; ribonuclease Y

cd16591
Location:12 → 61

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cd19761
Location:97 → 134

Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
XM_006508365.4 → XP_006508428.1 tripartite motif-containing protein 6 isoform X1

See identical proteins and their annotated locations for XP_006508428.1

UniProtKB/Swiss-Prot

B2RSQ8, Q8BGE7, Q99PQ6

UniProtKB/TrEMBL

A0A1L1SS93

Conserved Domains (4) summary

TIGR03319
Location:145 → 238

RNase_Y; ribonuclease Y

cd15823
Location:299 → 486

SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)

cd16591
Location:12 → 61

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cd19761
Location:97 → 134

Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
XM_006508366.4 → XP_006508429.1 tripartite motif-containing protein 6 isoform X1

See identical proteins and their annotated locations for XP_006508429.1

UniProtKB/Swiss-Prot

B2RSQ8, Q8BGE7, Q99PQ6

UniProtKB/TrEMBL

A0A1L1SS93

Related

ENSMUSP00000149805.2, ENSMUST00000214578.2

Conserved Domains (4) summary

TIGR03319
Location:145 → 238

RNase_Y; ribonuclease Y

cd15823
Location:299 → 486

SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)

cd16591
Location:12 → 61

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cd19761
Location:97 → 134

Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins
XM_006508364.3 → XP_006508427.1 tripartite motif-containing protein 6 isoform X1

See identical proteins and their annotated locations for XP_006508427.1

UniProtKB/Swiss-Prot

B2RSQ8, Q8BGE7, Q99PQ6

UniProtKB/TrEMBL

A0A1L1SS93

Conserved Domains (4) summary

TIGR03319
Location:145 → 238

RNase_Y; ribonuclease Y

cd15823
Location:299 → 486

SPRY_PRY_TRIM6; PRY/SPRY domain in tripartite motif-binding protein 6 (TRIM6), also known as RING finger protein 89 (RNF89)

cd16591
Location:12 → 61

RING-HC_TRIM5_like-C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins TRIM5, TRIM6, TRIM22, TRIM34 and similar proteins

cd19761
Location:97 → 134

Bbox2_TRIM5-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM5, TRIM6, TRIM22, TRIM34, TRIM38 and similar proteins