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    Fads2b fatty acid desaturase 2B [ Mus musculus (house mouse) ]

    Gene ID: 228151, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Fads2bprovided by MGI
    Official Full Name
    fatty acid desaturase 2Bprovided by MGI
    Primary source
    MGI:MGI:2687041
    See related
    Ensembl:ENSMUSG00000075217 AllianceGenome:MGI:2687041
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm113; Fads2p1; 4833423E24Rik
    Summary
    Predicted to enable oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water. Predicted to be involved in lipid metabolic process. Predicted to act upstream of or within fatty acid biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be integral component of membrane. Is expressed in jaw; olfactory epithelium; and submandibular gland primordium. Orthologous to human FADS2B (fatty acid desaturase 2B, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 4.0), ovary adult (RPKM 3.7) and 4 other tissues See more
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    Genomic context

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    See Fads2b in Genome Data Viewer
    Location:
    2 D; 2 49.68 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (85314436..85349279, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (85484092..85518935, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05015 Neighboring gene STARR-seq mESC enhancer starr_05016 Neighboring gene olfactory receptor family 5 subfamily AK member 24 Neighboring gene olfactory receptor family 5 subfamily AK member 25 Neighboring gene STARR-seq mESC enhancer starr_05017 Neighboring gene olfactory receptor family 5 subfamily G member 28, pseudogene 1 Neighboring gene olfactory receptor family 5 subfamily G member 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid desaturase 2-like protein FADS2B
    Names
    fatty acid desaturase 2-like protein FADS2P1
    fatty acid desaturase 2B, pseudogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081664.2 → NP_001075133.1  fatty acid desaturase 2-like protein FADS2B

      See identical proteins and their annotated locations for NP_001075133.1

      Status: PROVISIONAL

      Source sequence(s)
      BC120879
      Consensus CDS
      CCDS38168.1
      UniProtKB/Swiss-Prot
      Q0VAX3
      Related
      ENSMUSP00000097507.2, ENSMUST00000099923.2
      Conserved Domains (3) summary
      cd03506
      Location:206 → 456
      Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...
      pfam00173
      Location:64 → 138
      Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain
      pfam00487
      Location:201 → 459
      FA_desaturase; Fatty acid desaturase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      85314436..85349279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VAX3.1 GenPept UniProtKB/Swiss-Prot:Q0VAX3

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