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    Lin37 lin-37 DREAM MuvB core complex component [ Mus musculus (house mouse) ]

    Gene ID: 75660, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Lin37provided by MGI
    Official Full Name
    lin-37 DREAM MuvB core complex componentprovided by MGI
    Primary source
    MGI:MGI:1922910
    See related
    Ensembl:ENSMUSG00000036845 AllianceGenome:MGI:1922910
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810054G18Rik
    Summary
    Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Myb complex. Orthologous to human LIN37 (lin-37 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 17.2), adrenal adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lin37 in Genome Data Viewer
    Location:
    7 B1; 7 18.58 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30254866..30259289, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30555441..30559721, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene proline and serine rich 3 Neighboring gene STARR-positive B cell enhancer ABC_E9289 Neighboring gene microRNA 9769 Neighboring gene heat shock protein, alpha-crystallin-related, B6 Neighboring gene STARR-positive B cell enhancer ABC_E870 Neighboring gene STARR-positive B cell enhancer ABC_E1338 Neighboring gene STARR-positive B cell enhancer ABC_E4917 Neighboring gene presenilin enhancer gamma secretase subunit Neighboring gene U2 small nuclear RNA auxiliary factor 1-like 4 Neighboring gene IGF-like family receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence. Mages CF, et al. Elife, 2017 Sep 18. PMID 28920576, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thus, Lin37 is an essential component of DREAM complex that cooperates with Rb to induce quiescence.
      Title: The DREAM complex through its subunit Lin37 cooperates with Rb to initiate quiescence.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Myb complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription repressor complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein lin-37 homolog
    Names
    antolefinin
    antolefinine
    lin-37 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290569.1 → NP_001277498.1  protein lin-37 homolog isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction at the 5' end of an exon and intiates translation at a downstream AUG compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC167970, AK007858, BY707863
      Consensus CDS
      CCDS71930.1
      UniProtKB/TrEMBL
      E9Q0Q9, Q91WQ7
      Related
      ENSMUSP00000103799.2, ENSMUST00000108164.8
      Conserved Domains (1) summary
      pfam15306
      Location:72 → 228
      LIN37; LIN37

    2. NM_029377.2 → NP_083653.1  protein lin-37 homolog isoform 1

      See identical proteins and their annotated locations for NP_083653.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK007858
      Consensus CDS
      CCDS21098.1
      UniProtKB/Swiss-Prot
      Q9D8N6
      UniProtKB/TrEMBL
      Q91WQ7
      Related
      ENSMUSP00000048557.5, ENSMUST00000043975.11
      Conserved Domains (1) summary
      pfam15306
      Location:84 → 240
      LIN37; LIN37

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30254866..30259289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250734.4 → XP_011249036.1  protein lin-37 homolog isoform X1

      UniProtKB/TrEMBL
      Q91WQ7
      Conserved Domains (1) summary
      pfam15306
      Location:95 → 251
      LIN37

    2. XM_036153535.1 → XP_036009428.1  protein lin-37 homolog isoform X3

      Conserved Domains (1) summary
      pfam15306
      Location:5 → 161
      LIN37

    3. XM_017312369.3 → XP_017167858.1  protein lin-37 homolog isoform X2

      UniProtKB/TrEMBL
      Q91WQ7
      Conserved Domains (1) summary
      pfam15306
      Location:83 → 239
      LIN37
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8N6.1 GenPept UniProtKB/Swiss-Prot:Q9D8N6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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