Dmkn dermokine [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dmknprovided by MGI
Official Full Name: dermokineprovided by MGI
Primary source: MGI:MGI:1920962
See related: Ensembl:ENSMUSG00000060962 AllianceGenome:MGI:1920962
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SK30; SK89; cI-36; C130074A08; 1110014F24Rik
Summary: Acts upstream of or within cornified envelope assembly. Located in extracellular space. Is expressed in epidermis; nasal cavity epithelium; nose; posterior naris epithelium; and skin. Orthologous to human DMKN (dermokine). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 182.1), lung adult (RPKM 34.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.24 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30463181..30480491)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30763756..30781066)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpression of Dermokine-alpha enhances the proliferation and epithelial-mesenchymal transition of pancreatic tumor cells.
Title: Overexpression of Dermokine-α enhances the proliferation and epithelial-mesenchymal transition of pancreatic tumor cells.
Authors improved the knowledge of Dmkn expression in mouse and highlighted a role for Dmkn beta and gamma in cornification.
Title: Mice deficient for the epidermal dermokine β and γ isoforms display transient cornification defects.
These results suggest that dermokine-beta delays early cutaneous wound healing in part by inhibiting expression of CXC chemokines containing the ERL-sequence motif.
Title: Dermokine inhibits ELR(+)CXC chemokine expression and delays early skin wound healing.
Drmkn and Krtdap are the highest differentially expressed genes in epidermis embryonic development in mice.
Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
Dermokine gene is expressed in epithelial tissues other than the skin and this expression is transcriptionally and posttranscriptionally complex.
Title: Dermokine: an extensively differentially spliced gene expressed in epithelial cells.
identification of a novel gene (dermokine)giving rise to two splicing variants, both of which are expressed in the spinous layer of epidermis
Title: Identification of novel keratinocyte-secreted peptides dermokine-alpha/-beta and a new stratified epithelium-secreted protein gene complex on human chromosome 19q13.1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (4) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cornified envelope assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cornified envelope assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dermokine

Names: epidermis-specific secreted protein SK30/SK89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166173.1 → NP_001159645.1 dermokine isoform c precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).

Source sequence(s)

AC165340, AK081753

Consensus CDS

CCDS52183.1

UniProtKB/Swiss-Prot

Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0

UniProtKB/TrEMBL

E9Q2P1

Related

ENSMUSP00000129031.2, ENSMUST00000165887.8

Conserved Domains (1) summary

PRK13875
Location:22 → 155

PRK13875; conjugal transfer protein TrbL; Provisional
NM_001166174.1 → NP_001159646.1 dermokine isoform d precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 3. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AC165340, AK081753, BC064724

Consensus CDS

CCDS52184.1

UniProtKB/Swiss-Prot

Q6E0U6, Q6P253, Q6SZJ9, Q9D1D0

UniProtKB/TrEMBL

E9QLW8, E9QQ29

Related

ENSMUSP00000082831.5, ENSMUST00000085688.11

Conserved Domains (1) summary

PRK13875
Location:22 → 155

PRK13875; conjugal transfer protein TrbL; Provisional
NM_001369359.1 → NP_001356288.1 dermokine isoform e precursor

Status: VALIDATED

Source sequence(s)

AC165340

UniProtKB/TrEMBL

E9QQ29

Conserved Domains (1) summary

PRK13875
Location:22 → 155

PRK13875; conjugal transfer protein TrbL; Provisional
NM_028618.2 → NP_082894.1 dermokine isoform a precursor

See identical proteins and their annotated locations for NP_082894.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. The resulting isoform (1, also called alpha) has the same N- and C-termini but is shorter compared to isoform 3.

Source sequence(s)

AC165340, AK003695

Consensus CDS

CCDS39893.1

UniProtKB/Swiss-Prot

Q6P253

Related

ENSMUSP00000042300.8, ENSMUST00000041703.10
NM_172899.4 → NP_766487.3 dermokine isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (2, also called beta) has a shorter and distinct N-terminus compared to isoform 3.

Source sequence(s)

AC165340, AK081753, BC064724

Consensus CDS

CCDS39892.1

UniProtKB/TrEMBL

E9QLW7, E9QQ29

Related

ENSMUSP00000082834.5, ENSMUST00000085691.11

Conserved Domains (1) summary

PRK13875
Location:22 → 155

PRK13875; conjugal transfer protein TrbL; Provisional